The subject of the invention is a method for the treatment of biomedical implants for the improvement of antithrombogenic properties thereof. The mentioned biomedical implants are cardiovascular implants, especially artificial blood vessels and stents made from a polyethyleneterephtalate (PET) polymer. The method is based on the treatment of a surface of cardiovascular implants by an adequate combination of a dose of neutral oxygen atom and positively charged molecular and atomic oxygen ions. After having been treated by a dose of said atoms and ions, the surface of cardiovascular implants becomes less prone to binding of thrombocytes. The method is characterised in that the exposure to a mixture of neutral oxygen atoms and positively charged molecular and atomic oxygen ions in pulses is such that in an individual pulse a dose of neutral oxygen atoms is reached between 1020 m-2 and 1026 m-2, and the dose of charged molecular and atomic oxygen ions between 1016 m-2 and 1023 m-2, the interval between individual pulses is between 10 s and 300 s, and that the flow of neutral oxygen atoms and positively charged molecular and atomic oxygen ions onto the surface of an implant is approximately even.

The topic of the invention is an adhesive with the addition of liquid wood - that is liquefied lignocellulosic materials and/or wood, as a component of adhesives for the mass production of products made of bonded wood with a lower content of formaldehyde and the process of its preparation. The invention also allows the curing of the adhesive at lower temperatures thus resulting in energy savings. The adhesive is characterized by containing a melamine, melamine-formaldehyde, melamine-urea-formaldehyde or urea-formaldehyde adhesive or a combination of these adhesives and liquefied wood, that is added up to 50 % (w/w), where the liquefied wood is prepared from materials containing cellulose.

Invention represents fusion protein containing a chimeric flagellin composed of two different types of flagellin, which differ in the strength of activation of TLR5 receptor; vaccine, which contains the fusion protein or DNA coding for the fusion protein and the vaccine is used for treatment and prevention of infections with pathogenic bacteria, which contain flagellin that does not activate the TLR5. The new vaccine includes the fusion protein, which includes flagellin of bacteria that stimulate activation of TLR5. The amino- and carboxy- terminal segments of the Helicobacter pylori flagellin are replaced with the flagellin segments of bacteria, which triggers stimulation of TLR5, and the protein segments against which the immune response will be triggered are added; and optionally a signaling sequence that enables an appropriate localization of the protein is added. The invention also referrers to vaccines used for consecutive immunization, and a vaccine for a single consecutive immunization includes different fusion protein, which differs in part of flagellin that stimulates the TLR5 receptor, which is the way for prevention of neutralization of the fusion protein activity.

Presented is an improved design or redesign concept for synchronous sequential logic devices using an alternative type of registers. Further a suitable clock-tree concept for such registers is proposed. 2.2. The special registers typically use a third additional latch to the traditional two master- and slave latches. This introduces latency between the overtaking and forwarding of information bits, between two edges of one or two clocks. These registers can be clocked with extreme clock skewing. 2.3. This new approach changes advantageously the time margins for setup and hold time between combinational connected registers. The extreme skewing reduces the peak currents. The concept allows also reducing the power dissipation. Existing netlist based designs may be quickly adapted to the new technology just by changing the involved register types and optimizing the clock tree.

The invention relates to a rotor (10) with a rotor spider (11) which rotates about an axis, comprising a number of webs (12) and a laminated rim (14), made from individual rim sheets (16), concentrically surrounding the rotor spider (11) and connected to the rotor spider (11), by means of taper keys (13) in a laminated rim keyway. A simplified connection of laminated rim (14) to rotor spider (11) is achieved, whereby the keys (13) and the laminated sheets (16) are embodied such as to engage by forming a rigid positive fit.

The invention relates to an installation for fire-fighting in a tunnel, especially a road tunnel (1). Said installation comprises nozzle ducts (4) which extend along the tunnel roof (2), are divided into longitudinal sections (3), and are connected to nozzles (5, 6) for forming a spray, or receive such nozzles (5, 6). Said nozzle ducts are respectively connected, in sections, and by means of a valve (7), to a pressure line (8) for an extinguishing liquid. Said installation also comprises a control device (10) for the valves (7) between the pressure line (8) and the nozzle duct (4), said control device being connected to a device (11) for localising the source of fire. In order to create advantageous extinguishing conditions, auxiliary nozzles (6) are provided in addition to the main nozzles (5) which are oriented towards a region of the tunnel (1) floor, said auxiliary nozzles having a smaller diameter than the main nozzles (5) and being used to produce a spray in an upper region of the tunnel outside the spray region (19) of the main nozzles (5).

The invention relates to a sales unit for a non-food household article which is provided in the form a manipulable and useable object (3), embodied as a toy. Said object is formed by a base element (1), which is for sale, comprising a covering surface (4) and a closing lid (6), and a decorative element (2) which gives the whole object (3) a toy-like appearance. The aim of the invention is to provide a sales unit which allows the base element to be sufficiently recognized while making the product displayed on the sales shelf appealing to the consumer. To achieve this, the decorative element (2) only partially surrounds the covering surface (4) of the base element (1) along a section of the covering periphery. This means that the base element (1) forms an essentially visible part of the whole object (3).

This invention relates to a novel process to obtain hoghly pure 4-(cyclopropylcarbonyl)-α,α-dimethylphenylacetic acid of Formula I through crystallization from a mixture of para and meta regioisomers of Formula I and II in cyclohexane, whereby the amount of undesired meta isomer, 3-(cyclopropylcarbonyl)-α,$g)a)-dimethylphenylacetic acid of Formula II is decreased to below 0.5%. The compound of Formula I is a key intermediate for the preparation of high purity terfenadine carboxylate, which is a known antihistaminic.

In the production of potable alcohols, a continuous fermentation stage is employed to pitch and/or initially ferment a wort containing fermentable sugars. An exemplary continuous stage involves the use of a gas lift bioreactor employing superflocculant yeast and stringent oxygen control. The continuous stage can then be followed by sending an at least partially fermented discharge from the continuous process to a batch processing stage for finishing.

There is disclosed, a process for lactonization to produce highly pure simvastatin of Formula (1) which comprises lactonization of a compound of the Formula (II), where Z is H or NH4 in a mixture of acetonitrile and glacial acetic acid to provide anhydrous conditions at a temperature of 65-70 °C and wherein the dimer impurity of formula (III) formed is less tan 0.1, thereafter adding water to the reaction mixture thereby causing simvastatin of formula (I) to precipitate from the reaction mixture.