The present invention provides a pharmaceutical composition or crystalline composition with a specific dissolution profile, which comprises suberoylanilide hydroxamic acid or a pharmaceutically acceptable salt or hydrate thereof as an active ingredient. The present invention provides a process of producing said crystalline composition or pharmaceutical composition. The present invention also provides compositions with a specific particle size distribution.

The present invention relates to compounds having the structure Formula (I) useful as potassium channel inhibitors to treat cardiac arrhythmias.

A hands-free personal communication device is worn about a user's neck. The communication device includes an elongated elastic neckband for supporting the communication device about the user's neck. The elastic neckband has memory characteristic and is bendable along its length such that the neckband is formable into and out of various selectable positions. An acoustic output device is attached to the neckband and positioned near an ear of the user when the communication device is worn about the user's neck. A microphone is attached to an end of the neckband. A detachable earbud may be attached to an end of the neckband.

The invention relates to the field of mechanical engineering and materials. More specifically, the invention relates to a self-adjusting system of crossing rails having multiple characteristics which extend the useful life of the crossing system by at least a factor of four, while offering a safety support by providing redundancy to the line system. In this way, human passengers can move from place to place easily and safely with a minimum of noise and vibrations. In addition, the proprietor of the system can benefit from lower maintenance costs and less exposure to financial risk. Moreover, the system can be installed at a multitude of diverse natural sites without altering or damaging the environment. Moreover, the same components can be used to produce other configuration options which increase the possibility of creating a system having characteristics enabling same to cover a multitude of inclinations. According to the invention, the various components are combined in order to obtain (i) maximum conservation of energy, said configuration combining a smooth rail (Fig. 1) and the self-balancing system (Fig. 3), or (ii) maximum braking, said configuration combining the skeleton rail (Fig. 2) and the high-braking safety system (Fig. 4).

A method for incorporating instrumentation in determining sensory quality of citrus pulp in citrus juice by measuring, using image-based measurements, one or more parameters of the pulp in a sample of the citrus juice, linking the parameter measurements to sensory evaluations, and making a sensory determination of the quality of the pulp content in the juice, which is linked to consumers acceptance of the amount of pulp in the juice is disclosed.

This invention relates to methods for treating or preventing hepatitis C virus infections in mammals using Toll-Like Receptor (TLR)7 ligands and prodrugs thereof. More particularly, this invention relates to methods of orally administering a therapeutically effective amount of one or more prodrugs of TLR7 ligands for the treatment or prevention of hepatitis C viral infection. Oral administration of these TLR7 immunomodulating ligands and prodrugs thereof to a mammal provides therapeutically effective amounts and reduced undesirable side effects.

Substituted heteroaryl fused pyridine, pyrazine, and pyrimidine compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.

The present invention relates generally to the field of data migration and conversion from any source of data. More particularly, the present invention relates to the field of converting heterogeneous data to a user-defined format. For the purpose of sharing data, analyzing and deriving intelligent information from converted data. The present invention enables the features of relational database technologies to be used on non-relational database generated data without programming effort.

Recombinant polypeptides are disclosed that are useful for diagnosing American trypanosomiasis, or Chagas disease, a disease caused by the infectious agent Trypanosoma cruzi. Preferably, DNA sequences encoding the recombinant proteins are placed in plasmid vectors to be expressed in an organism.

The present invention is directed to a pharmaceutically acceptable taste masking liquid excipient base for administration of a relatively large amount of unpleasant tasting medicines. More particularly, the enhanced sweetness and taste masking effect are produced by the addition of sucralose to the excipient base with maintenance of a pH from about 2 to about 5. The invention is further directed to medicinal compositions comprising such a liquid excipient base and unpleasant tasting medicines. Still further, the invention is directed to a method for taste masking unpleasant tasting medicines through their incorporation into the claimed liquid excipient bases.