||WO||WO/2013/170863 - BIOREACTOR SYSTEM AND METHOD FOR CLONING THE PHYSIOLOGICAL STATE OF MICROORGANISMS||21.11.2013||
||PCT/EE2013/000005||TALLINN UNIVERSITY OF TECHNOLOGY||ERM, Sten|
Bioreactor system and method for cloning the physiological state of microorganisms comprises in preferred embodiment of a mother-reactor and one or more daughter-reactors with sensors, stirrers, fluid and gas flow channels, scales, pumps, controllers, computer, software, valves and accessory devices. The bioreactors are inter-connected with culture transfer hose. To achieve the method, the mother-reactor is filled with necessary volume, inoculated, stabilised in continuous cultivation, the microbial culture's volume is increased in variable volume cultivation while maintaining constant physiology, microbial culture is transferred from the mother-reactor into the daughter-reactors while maintaining constant physiology, experiment in the daughter reactor follows. After the experiment daughter-reactors are sterilized and rinsed. During the experiment culture volume in the mother-reactor is increased anew, after the experiment in the daughter-reactors is finished another culture transfer follows and next experiment is conducted. This sequence - variable volume cultivation, culture transfer, experiment - is repeated until necessary data has been acquired.
||WO||WO/2013/143552 - AN APPARATUS FOR DIAGNOSIS AND CONTROL OF HONEYBEE VARROATOSIS, IMAGE PROCESSING METHOD AND SOFTWARE FOR RECOGNITION OF PARASITE||03.10.2013||
||PCT/EE2013/000004||HUMAL, Priit||HUMAL, Priit|
An device for diagnosis and control of honeybee varroatosis (Varroa mite infection) comprises one or several cameras (310), connected to image processor (311). The software of the device is capable of processing the picture of honeybee, recognition the presence or absence of varroa mite on the body of the bee on the field-of-view of the cameras or in the chamber for observation, counting the infected and non-infected bees, separating the infected bees from non-infected bees or killing the recognized varroa mites. Controlled gates (314, 315, 316), valves, positioning actuators and/or heaters (329, 330) are used as output devices for realization of the said actions. The method of image processing for recognition of varroa mite or other parasites comprises of searching reflections in the image and analysis of the surroundings of the found reflections. Also the method for determination of location of body elements of insect in an image is disclosed.
||WO||WO/2013/139348 - SKIN CANCER BIOMARKER DETECTION BY INFRARED SPECTROSCOPY||26.09.2013||
||PCT/EE2013/000003||MC PROFESSIONAL LTD.||EIKJE, Natalja|
The present invention relates to a method for detection in IR (infrared) spectra of human epidermal skin tissue the presence of the multiplet around 1055 cm-1, i.e. the ratio of intensity of the nucleic acids bands, DNA and RNA, indicative for prognosis, diagnosis and prediction of epidermal skin cancers and precancers. Detection of the multiplet together with patterned appearance of DNA/RNA triad peaks at about 1071, 1084/1085 and 1095 cm-1 additionally indicates relation to certain types of tumour and malignancy, also indicating progression of malignancy and progression towards malignancy.
||WO||WO/2013/135249 - A FORMULA AND METHOD FOR MONITORING INDIVIDUAL METABOLIC RESPONSE AND FOR GENERATING PREDICTIVE MEDICAL METRICS||19.09.2013||
||PCT/EE2013/000002||MC PROFESSIONAL OÜ||EIKJE, Natalja|
Provided is a formula and method for monitoring individual metabolic response that involve calculation of the lag/latency time (LT) for the peak levels of measured a variety of glucose values by HATR-FTIR (horizontally attenuated total reflection Fourier transform infrared) spectroscopy and the LT for the peak level of capillary blood glucose (CBG), with subsequent calculation of the LT changes between them. Obtained meaningful time-dependent and dose-dependent glucose values and their LT changes characterize glycemic variability (GV) in a qualified subject, that can be used to predict the patient's risk of hyperglycemia, to stage Type II diabetes and, in general, to be considered as a new metrics of assessing the quality of metabolic control.
||WO||WO/2013/123950 - ANALYTICAL METHOD FOR COMMON AND SPECIFIC CHARACTERIZATION OF SKIN CARCINOGENESIS BY FTIR MICROSPECTROSCOPY||29.08.2013||
||PCT/EE2013/000001||MC PROFESSIONAL OÜ||EIKJE, Natalja|
The invention presents methods of using Fourier transform infrared (FTIR) microspectroscopy for common and specific characterization of carcinogenesis in human skin tumors. The invention provides the user with the method to analyse intra- and inter-molecular interactions for nucleic acids and proteins expressed in infrared (IR) spectra of human skin epidermal cancers towards understanding the molecular, cellular and tissue changes that occur during skin carcinogenesis. More particularly, presented analytical method has the advantage to simultaneously observe DNA-RNA, DNA-DNA, DNA-protein and protein-protein interactions by means of their expressed interacting activity levels within one type of tumour and between different types of tumours, both commonly and specifically, with further indication of the grade of activity in benign, premalignant and malignant skin tissue cells.
||WO||WO/2013/071939 - A METHOD AND A SYSTEM FOR DISPLAYING AND WATCHING THREE-DIMENSIONAL IMAGES ON THE SCREEN||23.05.2013||
||PCT/EE2012/000006||OÜ UNIPOWER||KUNIN, Leonid|
The invention provides method and system to enable a user to form 3D image frames sequence in a device comprising any type of screen and watch the 3D image on the screen of this device using respectively configured glasses. More precisely the invention is related to means to mark video frames used in displaying of 3D image, to display these markers to the screen, to detect the markers, to watch the frames by respective watching glasses and to synchronize of the frames. ˙
||WO||WO/2013/010553 - METHOD AND ANALYTICAL KIT FOR SIMULTANEOUS QUANTIFICATION OF B-COMPLEX VITAMIN CONTENT IN FOOD||24.01.2013||
||PCT/EE2012/000004||TALLINN UNIVERSITY OF TECHNOLOGY||HÄLVIN, Kristel|
The present invention relates to an analytical vitamin analysis kit, the method of its preparation, and the method of its application. The given analytical kit can be used for the simultaneous determination of the quantity of five B-complex vitamins (B l, B2, B3, B5 and B6) and individual vitamers in drugs, food, food- and bio-supplements, feed, and other biological samples using LC-MS isotope internal standard assay. The analytical kit is based on the use of sample vials containing lyophilized or dried isotope labelled internal standards of the B-complex vitamers with a mix of hydrolytic enzymes, used to convert vitamers and cofactors into the same chemical forms as the used isotope labelled internal standards, and for their following quantification by means of LC-MS or LC-MS/MS.
||WO||WO/2012/159638 - NON-CYTOTOXIC ALPHA VIRAL CONSTRUCT, CELL LINE AND COMPOSITION AND A METHOD FOR THE ASSESSMENT OF THE EFFECT OF ANTIVIRAL AGENTS.||29.11.2012||
||PCT/EE2012/000003||TARTU ÜLIKOOL (UNIVERSITY OF TARTU)||LULLA, Aleksei|
The invention relates to the field of molecular biology and comprises constructs based on non-cytotoxic alphaviral mutants capable to replicate in a stable manner ant to be maintained in mammalian cells as well as cell lines capable to replicate said constructs in a stable manner. The invention provides new constructs based on an alphavirus, in particular Chikungunya virus, which are feasible to apply in the creation of expression systems and research for and analysis of antiviral substances due to their non-cytotoxic nature. The invention enables the assessment of drug candidates for the screening of anti-alphaviral substances. Also, the invention can be applied for expressing recombinant proteins in genetic engineering systems.
||WO||WO/2012/126481 - ISOLATED MICROORGANISM STRAINS LACTOBACILLUS PLANTARUM MCC1 DSM 23881 AND LACTOBACILLUS GASSERI MCC2 DSM 23882 AND THEIR USE||27.09.2012||
||PCT/EE2012/000001||OÜ TERVISLIKU PIIMA BIOTEHNOLOOGIATE ARENDUSKESKUS||KULLISAAR, Tiiu|
The present invention relates to new microorganism strains L.plantarum MCCl DSM 23881 and L.gasseri MCC2 DSM 23882 and their use as antioxidant proteolytic ingredients for the production of food products and dietary supplements. Food products and dietary supplements containing L.plantarum MCCl and L.gasseri MCC2 are hypoallergenic, reduce milk allergy and lower urinary tract irritation symptoms accompanying benign prostatic hyperplasia and oxidative stress and inflammation associated with these.
||WO||WO/2012/116708 - METHOD OF SHOOT-THROUGH GENERATION FOR MODIFIED SINE WAVE Z-SOURCE, QUASI-Z-SOURCE AND TRANS-Z-SOURCE INVERTERS||07.09.2012||
||PCT/EE2012/000002||TALLINN UNIVERSITY OF TECHNOLOGY||VINNIKOV, Dmitri|
This invention belongs into the field of power electronics and semiconductor converter control and pertains to the method of shoot-through generation for modified sine wave Z-source, quasi-Z-source and trans-Z-source inverters. The inverter can be controlled using either the modified sine wave pulse-width modulation or phase-shift modulation method. There are three methods for shoot-through generation in the case of modified sine wave control: by overlapping active states, during the freewheeling state and during the zero state.