||WO||WO/2014/169885 - METHOD FOR ISOLATION OF ADIPOSE TISSUE-DERIVED STROMAL VASCULAR FRACTION CELLS||23.10.2014||
||PCT/CZ2014/000032||MICHALEK, Jaroslav||MICHALEK, Jaroslav|
The present invention provides a method of isolation of adipose tissue-derived stromal vascular fraction cells (SVF cells), wherein adipose tissue is washed using sterile normal saline solution, the washed adipose tissue is then resuspended in normal saline supplemented with sterile grade of collagenase and calcium gluconate, the suspension is then incubated for 10 to 60 minutes at 36 to 39 °C and subsequently centrifuged at 400 to 500g, after centrifugation the upper layer is removed and the normal saline solution is added to the pellet containing SVF cells to form a suspension, which is then passed through a filter to remove remaining larger tissue pieces. This method allows to achieve higher yields than the prior art methods.
||WO||WO/2014/169886 - EQUIPMENT FOR ACCESS CONTROL||23.10.2014||
||PCT/CZ2014/000037||COMINFO A.S.||KONFRŠT, Václav|
To control access of persons, especially access in and out of market shopping areas there is designed an equipment comprising a swing gate with a drive unit and a control unit, where the drive unit where the drive unit is provided with coaxially arranged direct-current motor (1) and electromagnetic friction brake (2), the brake friction disk (12) being coupled with a rotor (5) of the d-c motor (1).
||WO||WO/2014/161516 - OXA- AND THIA-DIAZOLES USEFUL IN THE TREATMENT OF TUBERCULOSIS||09.10.2014||
||PCT/CZ2013/000131||UNIVERZITA KARLOVA V PRAZE FARMACEUTICKA FAKULTA V HRADCI KRALOVE||HRABALEK, Alexandr|
A substituted diazole of genera l formula (1) wherein X is 0 or S; R is selected from the group consisting of: H, NH2-, C1-C11n alkyl, cyclohexyl-, benzyl-, phenyl-, pyridyl- or phenyl- substituted, in positions 2, 3, 4 or 5, by one or more electron-acceptor groups comprising -N02, -N(a lkyl)3, -CF3, CC13, -CN, -COOH, -COOAlk, -COOAr, -CHO, -COAlk, -COAr, -F, -CI, -Br, -I, and/or electron-donor groups comprising -NH2, -N Halkyl, -N(alkyl)2, -OH, -Oalkyl, -Oaryl, -NHCOCH3, -NHCOalkyl; -NHCOaryl; -alkyl, -aryl, wherein when R1 and R3 is -N02, then R2 a R4 is -H, or when R1 and R3 is -H, then R2 and R4 is -N02. These compounds can be prepared by easy synthesis and have low toxicity and significant activity against mycobacteria including their multiresistant strains. The invention provides also a pharmaceutical preparation having substituted diazole of formula (I) as the active ingredient, as well as the use of this substituted diazole as antituberculotic.
||WO||WO/2014/161517 - SKI||09.10.2014||
||PCT/CZ2014/000034||PETERKA, Dušan||PETERKA, Dušan|
According to the invention, the ski (1) comprises an end part (32) which extends together with the running surface (14) in a straight manner or is curved upwards. The lower side of the front part (8) of the base (6) of an attachment (4) rests on the upper side of the end part (32) of the ski (1). A nose-shaped section (33) extends downwards from said base (6) in the region of the end surface (31) of the end part (29) or in the region of the end surface (31) of the ski end part (29) which is connected to the end of the ski (1), said nose-shaped part resting securely on the adjacent end surface (31). The lower side of the base (6) of the attachment (4) extends on the adjacent lower side of the end part (29) continuously in the region of the nose-shaped part (33), and if the end part (32) of the running surface (14) is straight, it extends from the region of the nose-shaped part (33) in a continuously curved upwards manner counter to the direction of travel of the ski (1). A thin projection (7) extends downwards on each side of the base (6) of the attachment (4). Two guiding projections (34) having an elongate shape are arranged on the lower side (13) of the rear part (12) of the base (6) of the attachment (4) between the sides of the base (6). The heel part (16) of the safety binding (17) is secured to the support surface (21) of the base (6) of the attachment (4) and the front part (20) of the safety binding (17) is applied in front of said latter, on a second surface (22) on the upperside (18) of the ski (1).
||WO||WO/2014/154188 - METHOD OF PHASE GRADIENT RADIOGRAPHY AND ARRANGEMENT OF AN IMAGING SYSTEM FOR APPLICATION OF THE METHOD||02.10.2014||
||PCT/CZ2013/000045||INSTITUTE OF EXPERIMENTAL AND APPLIED PHYSICS||JAKŮBEK, Jan|
Radiation imaging method including steps of generation of at least one radiation microbeam by a radiation source, radiation penetration through the examined object and its caption by a detector, while the difference between the position of the non- refracted microbeam detected without the examined object and the position of the refracted microbeam detected with the examined object defines refraction angle in a particular point of the examined object expressing the size of local gradient of refractive index corresponding to the phase gradient image (PGI) of the examined object, while the radiation on the way from the source (1) to the detector (7) passes through a directing element (2) which forms and directs radiation microbeam to the boundaries between the pixels (14) of the detector (7) where the incident radiation particles generate an analog signal in the pixels (14) adjacent to the boundary and each of the pixels (14) detects the appropriate part of the signal, after which the difference (8) of the position between the refracted microbeam (5) and the non- refracted microbeam (6) is obtained from the change of the analog signal sharing within the appropriate pixels (14) adjacent to the boundary.
||WO||WO/2014/154189 - A METHOD OF PRODUCTION OF POTASSIUM NITRATE BY ELECTRODIALYSIS AND APPARATUS FOR MAKING THE SAME||02.10.2014||
||PCT/CZ2014/000030||MEMBRAIN S.R.O.||MACHUCA, Lubomir|
The invention concerns a method of production of potassium nitrate by means of electrodialysis, consisting in the exchange of ions between solution of potassium chloride and solution of ammonium nitrate, nitric acid or sodium nitrate. This exchange of ions occurs in electric field in a system of ion-exchange membranes (see Figure 1), containing at least one sequence of anion-exchange membranes (AM1, AM2) and cation-exchange membranes (CM1, CM2), alternating and creating at least four intermembrane spaces (C1, C2, D1, D2). In these intermembrane spaces on both sides of membranes, solutions of the said chemical compounds flow in the following manner: solution of input potassium chloride flows in the first interaiembrane space (D1) before the first anion-exchange membrane; solution of ammonium nitrate, nitric acid or sodium nitrate flows in the third intermembrane space (D2) between the first cation-exchange membrane (CM1) and the second anion-exchange membrane; while solution of the main product - potassium nitrate - flows in the fourth intermembrane space (C2) between the second anion-exchange membrane (AM2) and the second cation-exchange membrane (CM2), and solution of by-product - ammonium chloride, hydrochloric acid or sodium chloride - flows in the second intermembrane space (C1) between the first anion-exchange membrane (AMI) and the first cation-exchange membrane (CM1). The invention also concerns an apparatus to perform this method.
||WO||WO/2014/146622 - VAPOR PERMEABLE FOIL OR LAMINATE WITH ANTIMICROBIAL SURFACE TREATMENT||25.09.2014||
||PCT/CZ2014/000029||CENTRUM ORGANICKÉ CHEMIE S.R.O.||KOŘĺNKOVÁ, Radka|
Invention describes vapor permeable foil or laminate with antimicrobial surface treatment. On the surface of foil or laminate is created thin layer with photoactive compound. Photoactive compound is able react with light having wavelength from 400 nanometres to 700 nanometres. Thin layer with photoactive compound is permanently on the surface of foil or laminate.
||WO||WO/2014/139489 - METHOD FOR THE PREPARATION OF TICAGRELOR AND INTERMEDIATES SUITABLE THEREFORE||18.09.2014||
||PCT/CZ2014/000028||ZENTIVA K.S.||RIHA, Jaroslav|
A method for the preparation of ticagrelor of formula I, wherein the key reaction of the entire synthesis is condensation of an amino cyclopentane diol with pyrimidine, providing the isolated intermediate of formula IV. The amino cyclopentane diol is used for the reaction with pyrimidine without any protecting group on the hydroxyls in positions 1 and 2. Using the compound without a protecting group eliminates the necessity of deprotection in the subsequent synthetic steps.
||WO||WO/2014/139485 - A METHOD FOR THE PREPARATION OF 5-[(R)-2-(5,6-DIETHYL-INDAN-2-YLAMINO)-L-HYDROXYETHYL]- 8-HYDROXY-(1H)-QUINOLIN-2-ONE (INDACATEROL)||18.09.2014||
||PCT/CZ2014/000023||ZENTIVA, K.S.||MECA, Ludek|
The invention relates to a new method of synthesis of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)- 1-hydroxyethyl]-8-hydroxy-(1H)-quinolin-2-one of formula (R)-2, known under the generic name indacaterol, which is used for the treatment of chronic obstructive pulmonary disease (COPD). The method comprises preparation of the racemic intermediate 5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-benzyloxy-(1H)-quinolin-2-one of formula 1, which is further, in an arbitrary order, chirally resolved and debenzylated, and subsequently indacaterol of formula (R)-2 is isolated.
||WO||WO/2014/139488 - ROTARY TABLE FOR THE DEPOSITION OF THIN SURFACE FILMS ON SUBSTRATES||18.09.2014||
||PCT/CZ2014/000027||HVM PLASMA, SPOL.S.R.O.||DOSTÁL, Jan|
The purpose of the present invention is to provide rotary table (1) for deposition of thin surface layers onto substrate (21). Rotary table (1) is adapted for rotating the substrates (21) on three axes (4, 8, 18) of rotation (ω1, ω2, ω3). Resulting surface modification of the substrate (21) is performed over the entire surface with uniform thickness.