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Analysis

1.2021101338Composition and Methods for prevention of progression, recurrence and metastasis of lung cancer
AU 25.03.2021
Int.Class A61K 36/185
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
Appl.No 2021101338 Applicant AUSTRALIAN INSTITUTE FOR CANCER MEDICINE INNOVATION PTY LTD Inventor Dong, Qihan
The present invention lies in the field of cancer prevention. The invention relates to compositions and methods for prevention of progression, recurrence and metastasis of lung cancer in patients who have been diagnosed as having small (less than 1 cm) pulmonary nodule(s), or who have completed the standard treatment including surgical, chemo- or radio therapy, targeted therapy, or immuno-therapy and disease is in remission. Prior studies have established that not all cancer cells are in the proliferative state and some cancer cells are in a dormant state (i.e. residing at Go phase). As most therapies are targeting proliferating cells, cancer cells at dormant state are capable to evade the standard treatment and survive. Awakening of dormant cancer cells (i.e. exit from Go state and re-enter cell cycle) is known to contribute to cancer progression, recurrence and metastasis and confer poor clinical outcome including high mortality rates. This invention is about establishing a product which comprises extracts from Punica granatum peel (PGP) and Dioscorea Nipponica (DN). The application of the product can not only effectively block re-entering cell cycle, but also kill, dormant lung cancer cells. The mechanism to block awakening of dormant lung cancer cells is through AURORA A, SSRP1, SPT16, MYC, SKP2 and p27 proteins.
2.20110305699Treating Oral Cancer with Anti-IL-20 Antibody
US 15.12.2011
Int.Class A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Appl.No 12815927 Applicant National Cheng Kung University Inventor Chang Ming-Shi

Treating oral cancer with an anti-IL-20 antibody.

3.20130196868Methods and algorithms for aiding in the detection of cancer
US 01.08.2013
Int.Class G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Appl.No 13718457 Applicant 20/20 GENESYSTEMS, INC. Inventor Michael Lebowitz

A method of data interpretation from a multiplex cancer assay is described. The aggregate normalized score from the assay is transformed to a quantitative risk score quantifying a human subject's increased risk for the presence of cancer as compared to the known prevalence of the cancer in the population before testing the subject.

4.20080188434Role of FGF-20 in cancer diagnosis and treatment
US 07.08.2008
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Appl.No 11893086 Applicant Cold Spring Harbor Laboratory Inventor Powers Scott

The invention provides methods for diagnosing cancers in humans by detecting DNA amplifications in chromosomal region 8p22, which encompasses the FGF-20 gene and the EFHA2 gene. Also provided are cancer treatment methods using inhibitors of FGF-20 and EFHA2. The invention also provides methods for promoting successful regeneration of liver function. These methods can be used therapeutically to improve liver function following transplantation in both recipient and donor subjects.

5.2005210695Humanized anti-AF-20 monoclonal antibody
AU 31.08.2006
Int.Class C07K 16/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
Appl.No 2005210695 Applicant Nymox Corporation Inventor Averback, Paul A.
Novel humanized and chimeric antibodies, humanized antibody fragments, polypeptides sequences of such antibodies and derivatives thereof that specifically bind AF-20 are provided as well as methods for their manufacture. These humanized and chimeric antibodies, antibody fragments and polypeptide sequences are useful in the treatment of cancers that express AF-20, as well as for diagnostic purposes, e.g., for in vivo imaging of tumors or cancer cells that express AF-20.
6.20230372346TREATMENT REGIMENS FOR EXON-20 INSERTION MUTANT EGFR CANCERS
US 23.11.2023
Int.Class A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
Appl.No 18044236 Applicant CULLINAN PEARL CORP. Inventor Briggs MORRISON

Treatment regimens for exon 20 insertion mutant cancers with (S)—N-(4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl)acrylamide (Compound 1).

7.WO/2022/055895TREATMENT REGIMENS FOR EXON-20 INSERTION MUTANT EGFR CANCERS
WO 17.03.2022
Int.Class A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
Appl.No PCT/US2021/049314 Applicant CULLINAN PEARL CORP. Inventor MORRISON, Briggs
Treatment regimens for exon 20 insertion mutant cancers with (S)-N- (4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl)acrylamide (Compound 1).
8.2386633NOVEL CANCER ANTIGEN EEF2
EP 16.11.2011
Int.Class G01N 33/574
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
Appl.No 10729253 Applicant INT INST CANCER IMMUNOLOGY INC Inventor SUGIYAMA HARUO
The present invention provides a method for detecting cancer using a protein expressed in various cancers, and a pharmaceutical composition for the treatment or prevention of such cancer using the protein as an indicator. Furthermore, the present invention provides a pharmaceutical composition containing a cancer antigen peptide derived from the protein. More particularly, the method comprises the step of determining the presence or amount of an eEF2 polypeptide or an eEF2 antibody in a sample obtained from a subject.
9.6166029Method for treating cancer with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US 26.12.2000
Int.Class A61K 31/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
Appl.No 09080722 Applicant The Stehlin Foundation for Cancer Research Inventor Giovanella Beppino C.

A method of treating specific forms of cancer with water-insoluble 20(S)-camptothecin compounds with the closed-lactone ring intact and/or derivatives thereof is disclosed. The method includes administering the compounds intramuscularly, orally and transdermally.

10.WO/2004/080445METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER
WO 23.09.2004
Int.Class A61K 31/135
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
135having aromatic rings, e.g. methadone
Appl.No PCT/EP2003/050059 Applicant MOLECULAR ENGINES LABORATORIES SA Inventor TELERMAN, Adam
Methods of treating and managing cancer are disclosed, which comprises the administration of an antihistaminic agents or structurally/functionally related to compound, optionally in combination with one or more additional anti-cancer agents. Pharmaceutical compositions, including single unit dosage forms, and kits useful in the treatment and management of cancer are disclosed. Also disclosed is a method of determining effectiveness of a cancer treatment.