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Analysis

1 / 127
1.WO/2004/031386METHOD OF EXAMINING ATOPIC DERMATITIS
WO - 15.04.2004
Int.Class G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
 Appl.No PCT/JP2003/009808 Applicant GENOX RESEARCH, INC. Inventor ITOH, Mikito
A gene showing a difference in expression level between a rash site and a no-rash site in a patient with atopic dermatitis or a patient with psoriasis is found out. Also, a gene showing a difference in expression level between a no-rash site in such a disease and a normal subject is found out. It is clarified that these genes are useful as indicators in examining atopic dermatitis or psoriasis or screening a remedy therefor. That is to say, a method of examining atopic dermatitis or psoriasis and a method of screening a compound for treating these diseases based on the comparison of expression levels of these indicator genes.
2.102037958합성조절 sRNA 기반 동시다중 표적유전자 발현억제 시스템 및 그 제법
KR - 26.11.2019
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
 Appl.No 1020180073970 Applicant 한국과학기술원 Inventor 이상엽
본 발명은 합성조절 sRNA 기반의 동시다중(multiplex) 표적유전자 발현억제 시스템 및 그 제법에 관한 것으로, 보다 자세하게는 다양한 항생제 내성 유전자, 복제원점 및 합성조절 sRNA를 포함하는 벡터의 조합 및 제법, 상기 벡터의 조합으로 구성된 sRNA 라이브러리 및 이를 이용한 유용물질 생산 균주의 스크리닝 방법에 관한 것이다. 본 발명에 따른 동시다중 표적유전자 발현억제 시스템은 기존의 유전자 결실방법과는 달리 타겟 유전자의 서열을 변형하지 않으면서 특정 유전자의 발현을 효과적으로 억제할 수 있는 합성조절 sRNA 기반 유전자 발현조절 시스템으로서, 다양한 벡터를 포함하여 원핵생물에서 활용 가능한 다른 플라스미드들과 호환성 있게 사용될 수 있고 동시다중 도입이 가능하도록 설계하여 빠르고 효율적인 재조합 미생물 제조에 유용하다. 또한, 본 발명에서는 유전체 수준 합성 조절 sRNA 라이브러리를 간단하고 빠르게 새로운 플랫폼으로 이전할 수 있는 기술을 제공하며, 이는 유용물질을 고성능으로 생산하는 재조합 미생물 선별에 유용하다. 따라서, 본 발명은 산업적, 의학적으로 유용한 다양한 대사 산물의 생산 효율을 획기적으로 증가시킬 수 있는 재조합 균주의 제작에 유용하다.
3.WO/2020/004936MULTIPLEX TARGET GENE EXPRESSION INHIBITION SYSTEM BASED ON SYNTHESIS REGULATOR SRNA AND METHOD OF PRODUCING SAME
WO - 02.01.2020
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
 Appl.No PCT/KR2019/007729 Applicant KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY Inventor LEE, Sang Yup
The present invention relates to a multiplex expression inhibition system based on a synthesis regulator sRNA and a method of producing same, and more specifically, to a combination of vectors comprising a variety of antibiotic-resistance genes, an origins of replication, and a synthesis regulator sRNA; a method of producing same; an sRNA library consisting of said combination of vectors; and a method of screening for a bacterial strain producing an useful substance by using same. The multiplex target gene expression inhibition system according to the present invention is a gene expression regulation system based on a synthesis regulator sRNA that, unlike existing gene knock-out methods, can effectively inhibit the expression of a specific gene without altering the sequence of a target gene; comprises various vectors and thus can be used compatibly with other plasmids usable in prokaryotes; and is designed to enable multiplex introduction, and thus is advantageous in a fast and efficient production of recombinant microorganisms. Furthermore, the present invention provides a technology that enables simple and fast transferring a genome-level synthesis regulation sRNA library to a new platform, and said technology is useful in selection of recombinant microorganisms producing useful substances in high capacity. Accordingly, the present invention is useful in the production of recombinant bacterial strains capable of dramatically increasing the production efficiency of a variety of medically useful metabolites.
4.1020140120093SCLERONEPHTHYA GRACILLIMUM GENE RESPONDING TO EXPOSURE TO TEMPERATURE LOWERING AND METHOD FOR CHECKING ENVIRONMENTAL CHANGE IN MARINE ECOSYSTEM USING SAME
KR - 13.10.2014
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
 Appl.No 1020130035742 Applicant 한국해양과학기술원 Inventor WOO, SEON OCK
The present invention relates to a Scleronephthya gracillimum-derived gene responding to the temperature lowering of the sea water and a method for checking the environmental change in a marine ecosystem using the same. Specifically, particular gene groups derived from Scleronephthya gracillimum exhibit a specific expression change due to the temperature lowering caused by the climate change, and therefore, these genes can be useful as biomarkers, for a microarray and kit for checking the exposure to the temperature lowering caused by the temperature change of the sea water. COPYRIGHT KIPO 2015
5.WO/2013/105807NOVEL SYNTHESIS-REGULATING SRNA AND METHOD FOR PREPARING SAME
WO - 18.07.2013
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
 Appl.No PCT/KR2013/000235 Applicant KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY Inventor LEE, Sang Yup
The present invention relates to a customized synthesized sRNA for reducing gene expression in a prokaryotic cell having a new structure, to a method for preparing the synthesized sRNA and to a use of the synthesized sRNA. More particularly, the present invention relates to a synthesized sRNA which contains an Hfg binding site derived from any one sRNA of MicC, SgrS and MicF, and a zone for forming complementary binding with target gene mRNA. The present invention also relates to a method for preparing the synthesized sRNA and to a use of the synthesized sRNA. The synthesized sRNA according to the present invention has the advantages of regulating the degree of inhibition by regulating the binding force to mRNA of the target gene, and can be effectively produced without deleting an existing gene through synthesized sRNA for regulating gene expression and may reduce an expression of the target gene, thus enabling the synthesized sRNA of the present invention to be valuably used in the production of recombinant microorganisms. The synthesized sRNA of the present invention may be quickly applied to various strains, and therefore, is very suitable for measuring the metabolizability of each strain and selecting an optimum strain. In addition, recombinant microorganisms for producing tyrosine or cadaverine at a high efficiency according to the present invention, obtained by regulating metabolic flux of microorganisms by means of synthesized sRNA can be valuably used as microorganisms for drugs and industrial solvents. That is, selecting an expression inhibitory target gene for high efficiency production of metabolites can be easily performed using the sRNA of the present invention. Thus, the sRNA of the present invention can be used in producing recombinant strains for the efficient production of various metabolites and in establishing methods for producing efficient production, and thus is very useful.
6.1020090119071KIT FOR DIAGNOSIS OF CIRRHOSIS CONTAINING PRIMER FOR AMPLIFYING CIRRHOSIS-SPECIFIC GENE
KR - 19.11.2009
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
 Appl.No 1020080044902 Applicant DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION Inventor KIM, SO YOUN
PURPOSE: A kit for diagnosing cirrhosis and a nucleic acid chip are provided to measure expression level of gene and simply diagnose cirrhosis. CONSTITUTION: A kit for diagnosing cirrhosis contains a primer for amplifying gene of which expression is decreased or increased in cirrhosis. The cirrhosis is hepatitis B virus-related cirrhosis. A nucleic acid chip for cirrhosis diagnosis contains a probe which is hybridizable with the gene in lesion of cirrhosis. COPYRIGHT KIPO 2010
7.1020140100157METHOD FOR PREDICTING NUTRITIONAL CONDITION AND MEAT QUALITY OF PIG USING GENE EXPRESSION PATTERN
KR - 14.08.2014
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
 Appl.No 1020130013076 Applicant GYEONGNAM NATIONAL UNIVERSITY OF SCIENCE AND TECHNOLOGY INDUSTRY-ACADEMIC COOPERATION FOUNDATION Inventor 김철욱
The present invention relates to a method for analyzing a gene expression pattern and, more specifically, to an analysis of selecting genes of a pig which is expressed differently according to the feeding of waste mushroom medium-fermented feed. According to the present invention, a gene, which is expressed differently by feeding the waste mushroom medium-fermented feed, is selected; a microarray or a kit for predicting pork is manufactured using the same, and the nutrition condition and the meat quality can be predicted by using the same. COPYRIGHT KIPO 2014
8.1020130082474NOVEL SYNTHETIC REGULATORY sRNA AND A METHOD FOR PREPARING THE SAME
KR - 19.07.2013
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
 Appl.No 1020130003438 Applicant KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY Inventor LEE, SANG YUP
PURPOSE: A synthetic sRNA is provided to regulate a binding force between a target gene and mRNA and to prepare a recombinant microorganism. CONSTITUTION: An sRNA suppresses gene expression in prokaryotes. The sRNA has a region of a complementary bond with the mRNA of a target gene and the Hfq binding site derived from sRNA of MicC, SgrS, or MicF. A method for preparing sRNA comprises the step of connecting a nucleic acid encoding the region of a complementary bond to a nucleic acid encoding the Hfq binding site. A method for suppressing the expression of the target gene comprises the steps of: transducing or expressing the sRNA in prokaryotes; and suppressing the mRNA expression of the target gene. COPYRIGHT KIPO 2013 null
9.1020200043274COMPOSITION FOR MODULATING LIPID METABOLISM, COMPRISING NOVEL GINSENOSIDE
KR - 27.04.2020
Int.Class A61K 31/7048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
 Appl.No 1020190119056 Applicant AMOREPACIFIC CORPORATION Inventor HONG YONG DEOG
The present application relates to a composition comprising, as an effective component, novel ginsenoside (20S,24R)-6-O- beta;-D-glucopyranosyl(1- gt;2)- beta;-D-glucopyranoside-dammar-3-one-20,24-epoxy-6a,12b,25-triol, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof. The composition exhibits excellent modulatory effects on lipid metabolism and cholesterols. COPYRIGHT KIPO 2020
10.1020230168533피지 분비 억제용 조성물
KR - 14.12.2023
Int.Class A61K 8/49
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
 Appl.No 1020220069140 Applicant (주)아모레퍼시픽 Inventor 손의동
본 개시는 화학식 1로 표시되는 화합물, 그 염, 그 입체 이성질체, 그 수화물 또는 그 용매화물을 유효성분으로 포함하는 피지 생성 억제용 조성물에 관한 것이다. 구체적으로, 상기 조성물로 세포 내 지질 합성을 억제하여 피지 생성을 억제할 수 있으며, 더욱 구체적으로는, 상기 피지 생성 억제용 조성물로 세포 내 지질 합성에 관련이 있는 인자들의 발현량을 감소시킴으로써 피부의 피지 생성을 억제시킬 수 있다.
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