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8. (WO2012158016) A METHOD FOR REGULATING BIOSYNTHESIS OF MONOLIGNOLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/158016    International Application No.:    PCT/MY2012/000014
Publication Date: 22.11.2012 International Filing Date: 30.01.2012
IPC:
C12N 9/88 (2006.01), A01H 1/00 (2006.01), C07K 14/415 (2006.01), C12N 15/29 (2006.01), C12N 15/60 (2006.01), C12N 15/82 (2006.01)
Applicants: UNIVERSITI SAINS MALAYSIA [MY/MY]; 11800 USM Penang (MY) (For All Designated States Except US).
ALAM, Maqsudul [US/MY]; (MY) (For US Only).
MOHD NAJIMUDIN, Mohd Nazalan [MY/MY]; (MY) (For US Only).
SAITO, Jennifer Ann [US/MY]; (MY) (For US Only).
OTHALATHARA USHARRAJ, Abhilash [IN/MY]; (MY) (For US Only)
Inventors: ALAM, Maqsudul; (MY).
MOHD NAJIMUDIN, Mohd Nazalan; (MY).
SAITO, Jennifer Ann; (MY).
OTHALATHARA USHARRAJ, Abhilash; (MY)
Agent: LOK CHOON HONG; Pintas IP Group No. 19, Jalan SS1/36 47300 Petaling Jaya Selangor Darul Ehsan (MY)
Priority Data:
PI 2011002234 19.05.2011 MY
Title (EN) A METHOD FOR REGULATING BIOSYNTHESIS OF MONOLIGNOLS
(FR) PROCÉDÉ DE RÉGULATION DE LA BIOSYNTHÈSE DE MONOLIGNOLS
Abstract: front page image
(EN)A method for reducing the synthesis of monolignols in cytoplasm of the plant of Hevea brasiliensis, comprising the step of down-regulating expression of a nucleic acid template containing at least one nucleotide sequence set forth in SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4, SEQ ID NO. 5, SEQ ID NO. 6, SEQ ID NO. 7, SEQ ID NO. 8, SEQ ID NO. 9, SEQ ID NO. 10, SEQ ID NO. 1 1 or SEQ ID NO. 12 in at least one cell. Also claimed are nucleotide sequences encoding phenylalanine ammonia-lyase 1 (PALI), phenylalanine ammonia-lyase 2 (PAL2), cinnamate 4-hydroxylase (CH4), coumarate 3-hydroxylase 1 (C3H1), coumarate 3-hydroxylase 2 (C3H2), caffeic acid/5-hydroxyconiferaldehyde O-methyltransferase (COMT), Hydroxycinnamoyl-CoA:shikimate hydroxycinnamoyl transferase (HCT), ferulate 5-hydroxylase (F5H), 4-coumarate CoA ligase (4CL), 4-coumarate caffeoyl-CoA O-methyltransferase (CCoAOMT), 4-coumarate cinnamoyl coenzyme A reductase (CCRl), and 4-coumarate cinnamyl alcohol dehydrogenase (CAD) enzymes, all from Hevea brasiliensis.
(FR)La présente invention a pour objet un procédé pour la réduction de la synthèse de monolignols dans le cytoplasme de la plante d'Hevea brasiliensis, comprenant l'étape de régulation à la baisse de l'expression d'une matrice d'acide nucléique contenant au moins une séquence de nucléotides présentée dans SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4, SEQ ID NO. 5, SEQ ID NO. 6, SEQ ID NO. 7, SEQ ID NO. 8, SEQ ID NO. 9, SEQ ID NO. 10, SEQ ID NO. 11 ou SEQ ID NO. 12 dans au moins une cellule. La présente invention concerne également des séquences de nucléotides codant les enzymes phénylalanine ammoniac-lyase 1 (PAL1), phénylalanine ammoniac-lyase 2 (PAL2), cinnamate 4-hydroxylase (CH4), coumarate 3-hydroxylase 1 (C3H1), coumarate 3-hydroxylase 2 (C3H2), acide caféique/5-hydroxyconiféraldéhyde O-méthyltransférase (COMT), hydroxycinnamoyl-CoA:shikimate hydroxycinnamoyl transférase (HCT), férulate 5-hydroxylase (F5H), 4-coumarate CoA ligase (4CL), 4-coumarate cafféoyl-CoA O-méthyltransférase (CCoAOMT), 4-coumarate cinnamoyl coenzyme A réductase (CCRl), et 4-coumarate alcool cinnamylique déshydrogénase (CAD), toutes issues d'Hevea brasiliensis.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)