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15. (WO2012014228) A METHOD TO BY-PASS ALLOSTERIC DOMAIN ACTIVITY OF AN ENZYME SO AS TO ALTER ITS FEEDBACK OR FEED-FORWARD INHIBITION OR ACTIVATION
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Latest bibliographic data on file with the International Bureau   
Pub. No.:    WO/2012/014228    International Application No.:    PCT/IN2011/000496
Publication Date: 02.02.2012 International Filing Date: 27.07.2011
IPC:
C12N 9/00 (2006.01), C12P 13/02 (2006.01), C12N 9/10 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13
Preparation of nitrogen-containing organic compounds
02
Amides, e.g. chloramphenicol
[IPC code unknown for ERROR IPC Code incorrect: invalid section (A=>H)!]
Applicants: SINGH, Abhishek, Narain [IN/IN]; (IN)
Inventors: SINGH, Abhishek, Narain; (IN)
Agent: DAVAR, G., S.; L.S. Davar & Co. 5/1, Kalkaji Extension New Delhi-110019 (IN)
Priority Data:
1760DEL/2010 28.07.2010 IN
Title (EN) A METHOD TO BY-PASS ALLOSTERIC DOMAIN ACTIVITY OF AN ENZYME SO AS TO ALTER ITS FEEDBACK OR FEED-FORWARD INHIBITION OR ACTIVATION
(FR) MÉTHODE POUR SUPPLANTER L'ACTIVITÉ DU DOMAINE ALLOSTÉRIQUE D'UNE ENZYME DE FAÇON À MODIFIER SA RÉTROINHIBITION OU SON ACTIVATION
Abstract: front page image
(EN)A method to bypass allosteric domain activity of an enzyme so as to alter the feedback/ feed-forward inhibition/ activation, comprises of (i) a method of increasing the downstream metabolic product such in fermentation or for genetically modified crop, where the wild type organism is feedback or feed-forward inhibited at one of its enzymatic reaction by introducing transgene to be expressed in a common cellular compartment such as cytosol and (ii) a method of decreasing the down stream metabolic product such as for therapeutic purpose, such as controlling the uncontrolled growth of tumor, where the wild type organism is feedback or feed-forward activated at one of its enzymatic reaction, by introducing transgene to be expressed in a common cellular compartment cytosol for that enzyme.
(FR)Selon l'invention, une méthode destinée à supplanter l'activité du domaine allostérique d'une enzyme de façon à modifier sa rétroinhibition ou son activation consiste à: i) augmenter le produit métabolique aval, notamment en fermentation ou pour des cultures génétiquement modifiées, l'organisme de type sauvage étant rétroinhibé ou activé au niveau d'une de ses réactions enzymatiques, par introduction du transgène à exprimer dans un compartiment cellulaire commun tel que le cytosol; et ii) réduire le produit métabolique aval, notamment à des fins thérapeutiques, par contrôle de la croissance débridée des tumeurs, l'organisme de type sauvage étant rétroinhibé ou activé au niveau d'une de ses réactions enzymatiques, par introduction du transgène à exprimer dans un compartiment cellulaire commun tel que le cytosol pour cette enzyme.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)