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200. (WO2011119722) USE OF ANATABINE TO TREAT INFLAMMATION AND METHODS OF SYNTHESIZING ANATABINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/119722    International Application No.:    PCT/US2011/029613
Publication Date: 29.09.2011 International Filing Date: 23.03.2011
IPC:
A61K 31/4458 (2006.01), A61P 29/00 (2006.01)
Applicants: ROCK CREEK PHARMACEUTICALS, INC. [US/US]; 55 Blackburn Center Gloucester, Massachusetts 01930 (US) (For All Designated States Except US).
WILLIAMS, Jonnie R. [US/US]; (US) (For US Only).
PUTHIAPARAMPIL, Tom Thomas [IN/IN]; (IN) (For US Only).
DAVID, Thomas Kanathkunn [IN/IN]; (IN) (For US Only).
RAJU, Muppala Sarveswara [US/US]; (US) (For US Only)
Inventors: WILLIAMS, Jonnie R.; (US).
PUTHIAPARAMPIL, Tom Thomas; (IN).
DAVID, Thomas Kanathkunn; (IN).
RAJU, Muppala Sarveswara; (US)
Agent: RIVARD, Paul M.; Banner & Witcoff, Ltd. 1100 13th Street NW Suite 1200 Washington, District of Columbia 20005 (US)
Priority Data:
12/729,346 23.03.2010 US
61/383,811 17.09.2010 US
61/384,447 20.09.2010 US
61/439,473 04.02.2011 US
61/439,483 04.02.2011 US
Title (EN) USE OF ANATABINE TO TREAT INFLAMMATION AND METHODS OF SYNTHESIZING ANATABINE
(FR) UTILISATION D'ANATABINE POUR TRAITER L'INFLAMMATION ET PROCÉDÉS DE SYNTHÈSE DE L'ANATABINE
Abstract: front page image
(EN)Pharmaceutical compositions comprising an isolated form of anatabine or a salt thereof can be used to treat disorders comprising an inflammatory component, including chronic, low-level inflammation. In another aspect, methods for the synthetic preparation of anatabine involve reacting benzophenoneimine with 3-aminomethyl pyridine to form benzylhydrylidene-pyridin-3-yl-methyl-amine. The benzylhydrylidene-pyridin-3-yl-methyl-amine is treated with a non-nucleophilic base and a dielectrophile, such as cis-1,4-dichloro-2-butene, followed by acidification, then basification, to provide anatabine.
(FR)Cette invention concerne des compositions pharmaceutiques contenant une forme isolée d'anatabine ou un sel de celle-ci qui peuvent être utilisées pour traiter les troubles ayant une composante inflammatoire, comprenant l'inflammation chronique, de bas niveau. Selon un autre aspect, des procédés de synthèse d'anatabine impliquent la réaction d'un benzophénoneimine avec une 3-aminométhylpyridine pour former une benzylhydrylidène-pyridin-3-yl- méthyl-amine. La benzylhydrylidène-pyridin-3-yl-méthyl-amine est traitée avec une base non-nucléophile et un diélectrophile, tel que le cis-1,4- dichloro-2-butène, acidifiée, puis basifiée, pour obtenir l'anatabine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)