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1. (WO2011116151) ENZYME-LOGIC BIOSENSING
PCT Biblio. Data
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Latest bibliographic data on file with the International Bureau   
Pub. No.:    WO/2011/116151    International Application No.:    PCT/US2011/028747
Publication Date: 22.09.2011 International Filing Date: 16.03.2011
IPC:
C12Q 1/26 (2006.01), C12Q 1/48 (2006.01), G01N 33/15 (2006.01), G01N 33/50 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
26
involving oxidoreductase
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
48
involving transferase
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
15
Medicinal preparations
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street 5th Floor Oakland, CA 94607-5200 (US) (For All Designated States Except US).
CLARKSON UNIVERSITY [US/US]; 8 Clarkson Avenue P.O. Box 5630 Potsdam, NY 13699-5630 (US) (For All Designated States Except US).
WANG, Joseph [US/US]; (US) (For US Only).
WINDMILLER, Joshua, Ray [US/US]; (US) (For US Only).
SANTHOSH, Padmanabhan [IN/US]; (US) (For US Only).
CHUANG, Min-Chieh [--/US]; (US) (For US Only).
KATZ, Evgeny [IL/US]; (US) (For US Only).
HALÁMEK, Jan [CZ/US]; (US) (For US Only).
BOCHAROVA, Vera [RU/US]; (US) (For US Only).
PITA, Marcos [ES/ES]; (ES) (For US Only).
PRIVMAN, Vladimir [US/US]; (US) (For US Only)
Inventors: WANG, Joseph; (US).
WINDMILLER, Joshua, Ray; (US).
SANTHOSH, Padmanabhan; (US).
CHUANG, Min-Chieh; (US).
KATZ, Evgeny; (US).
HALÁMEK, Jan; (US).
BOCHAROVA, Vera; (US).
PITA, Marcos; (ES).
PRIVMAN, Vladimir; (US)
Agent: LEE, Hwa, C.; Perkins Coie LLP P.O. Box 1247 Seattle, WA 98111-1247 (US)
Priority Data:
61/314,494 16.03.2010 US
61/329,512 29.04.2010 US
Title (EN) ENZYME-LOGIC BIOSENSING
(FR) BIODÉTECTION À LOGIQUE ENZYMATIQUE
Abstract: front page image
(EN)Techniques, apparatus and systems are disclosed for implementing enzyme-logic based diagnosis that uses patterns of multiple markers and biochemical processing of the signal information for reliably identifying cardiac abnormalities and providing a final digital binary answer. In one aspect, a biochemical logic sensing system includes a network of enzyme- biocatalyzed logic gates adapted to receive biomarker input signals and perform an enzyme- biocatalyzed reaction resembling a Boolean logic operation using the received biomarker input signals to generate an output signal of the enzyme-biocatalyzed reaction. A signal processing unit is connected to the network of enzyme-biocatalyzed logic gates. The signal processing unit processes the generated output signal of the enzyme-biocatalyzed reaction and generates a digital binary output having a value of zero or one. The generated digital binary output indicates a type of an injury.
(FR)L'invention concerne des techniques, des appareils et des systèmes pour mettre en œuvre un diagnostic fondé sur une logique enzymatique qui utilise des motifs de marqueurs multiples et un traitement biochimique de l'information du signal pour identifier, de manière fiable, les anomalies cardiaques et apporter une réponse binaire numérique finale. Selon un aspect de l'invention, un système de détection logique biochimique comprend un réseau de portes logiques à biocatalyse enzymatique conçues pour recevoir des signaux entrants de biomarqueur et pour effectuer une réaction biocatalysée par une enzyme ressemblant à une opération logique Booléenne à l'aide des signaux d'entrée de biomarqueur reçus pour générer un signal de sortie de la réaction biocatalysée par une enzyme. Une unité de traitement de signal est connectée au réseau de portes logiques à biocatalyse enzymatique. L'unité de traitement de signal traite le signal de sortie généré de la réaction biocatalysée par une enzyme et génère un signal de sortie numérique binaire ayant une valeur de zéro ou de un. Le signal de sortie numérique binaire généré indique un type de lésion.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)