US2011023320 VACCINE AND METHODS OF USE AGAINST <i>STRONGYLOIDES STERCORALIS</i> INFECTION

1. (WO2011097216) VACCINE AND METHODS OF USE AGAINST STRONGYLOIDES STERCORALIS INFECTION

Latest bibliographic data on file with the International Bureau

Pub. No.:		WO/2011/097216		International Application No.:		PCT/US2011/023320
Publication Date:		11.08.2011		International Filing Date:		01.02.2011

IPC:

A61K 39/00 (2006.01), C07K 14/435 (2006.01)

Applicants:

THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Office of Technology Transfer National Institutes of Health 6011 Executive Boulevard, Suite 325 MSC 7660 Bethesda, Maryland 20892-7660 (US) (For All Designated States Except US).
THOMAS JEFFERSON UNIVERSITY [US/US]; 1020 Walnut Street Philadelphia, PA 19107 (US) (For All Designated States Except US).
NUTMAN, Thomas, B. [US/US]; (US) (For US Only).
ABRAHAM, David [US/US]; (US) (For US Only)

Inventors:

NUTMAN, Thomas, B.; (US).
ABRAHAM, David; (US)

Agent:

JAY, Jeremy, M.; Leydig, Voit & Mayer Two Prudential Plaza, Suite 4900 180 N. Stetson Avenue Chicago, Illinois 60601 (US)

Priority Data:

61/301,426

04.02.2010

Title

(EN) VACCINE AND METHODS OF USE AGAINST STRONGYLOIDES STERCORALIS INFECTION
(FR) VACCIN ET PROCÉDÉS D'UTILISATION CONTRE UNE INFECTION PAR STRONGYLOIDES STERCORALIS

Abstract:

(EN)The polynucleotide encoding the SSIR gene from the nematode Strongyloides stercoralis is provided, along with the polypeptide encoded by the SSIR gene. It was found that when mice were immunized with the SSIR polypeptide vaccine, it provided immunity to mice which were implanted with Strongyloides stercoralis L3 implants. Methods for making the SSIR protein, recombinant vectors encoding the SSIR gene, a vaccine made from the SSIR protein, and methods of use are also provided.
(FR)La présente invention concerne un polynucléotide codant pour le gène SSIR du nématode Strongyloides stercoralis, ainsi que le polypeptide codé par le gène SSIR. Il a été observé que lorsque des souris sont immunisées avec le vaccin de polypeptide SSIR, cela confère une immunité aux souris qui ont été implantées avec des implants de Strongyloides stercoralis L3. La présente invention concerne en outre des procédés pour préparer la protéine SSIR, des vecteurs recombinants codant pour le gène SSIR, un vaccin préparé à partir de la protéine SSIR, et des procédés d'utilisation.

Designated States:

AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).

Publication Language:	English (EN)
Filing Language:	English (EN)