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1. (WO2010011537) INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/011537    International Application No.:    PCT/US2009/050637
Publication Date: 28.01.2010 International Filing Date: 15.07.2009
IPC:
A61K 31/554 (2006.01), A61K 31/165 (2006.01), A61K 31/421 (2006.01), A61K 31/4245 (2006.01), A61K 31/433 (2006.01), A61K 31/4355 (2006.01), A61K 31/437 (2006.01), A61P 33/06 (2006.01)
Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Office of Technology Transfer National Institutes of Health 6011 Executive Boulevard, Suite 325 MSC 7660 Bethesda, MD 20892-7660 (US) (For All Designated States Except US).
DESAI, Sanjay, A. [US/US]; (US) (For US Only).
PILLAI, Ajay, D. [IN/US]; (US) (For US Only)
Inventors: DESAI, Sanjay, A.; (US).
PILLAI, Ajay, D.; (US)
Agent: PILLAI, Xavier; (US)
Priority Data:
61/083,000 23.07.2008 US
Title (EN) INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS
(FR) INHIBITEURS DU CANAL ANIONIQUE DE SURFACE DE PLASMODIUM EN TANT QU'ANTIPALUDIQUES
Abstract: front page image
(EN)Disclosed are inhibitors of the plasmodial surface anion channel (PSAC) inhibitors and the use thereof in treating or preventing malaria in an animal such as a human, comprising administering an effective amount of an inhibitor or a combination of inhibitors. An example of such an inhibitor is a compound of formula I, Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R7 are as described herein.
(FR)L'invention porte sur des inhibiteurs du canal anionique de surface de plasmodium (PSAC) et sur leur utilisation dans le traitement ou la prévention du paludisme dans un animal tel qu'un être humain, comprenant l'administration d'une quantité efficace d'un inhibiteur ou d'une combinaison d'inhibiteurs. Un exemple d'un tel inhibiteur est un composé de formule I, Formule 1 (I) ou un sel pharmaceutiquement acceptable de celui-ci, dans laquelle R1 à R7 sont tels que décrits dans la description.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)