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1. (WO2008070350) METHODS AND COMPOSITIONS RELATED TO WRAPPING OF DEHYDRONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/070350    International Application No.:    PCT/US2007/082893
Publication Date: 12.06.2008 International Filing Date: 29.10.2007
IPC:
C07D 401/14 (2006.01), A61K 31/506 (2006.01), A61P 35/02 (2006.01)
Applicants: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 West 7th St., Austin, TX 78701 (US) (For All Designated States Except US).
RICE UNIVERSITY [US/US]; P.O. Box 1892, Houston TX 77251-1892 (US) (For All Designated States Except US).
FERNANDEZ, Ariel [US/US]; (US) (For US Only).
BORNMANN, William [US/US]; (US) (For US Only).
LOPEZ-BERESTEIN, Gabriel [US/US]; (US) (For US Only).
SANGUINO, Angela [US/US]; (US) (For US Only).
PENG, Zhenghong [US/US]; (US) (For US Only)
Inventors: FERNANDEZ, Ariel; (US).
BORNMANN, William; (US).
LOPEZ-BERESTEIN, Gabriel; (US).
SANGUINO, Angela; (US).
PENG, Zhenghong; (US)
Agent: LANDRUM, Charles, P.; Fulbright & Jaworski L.L.P., 600 Congress Avenue, Suite 2400, Austin, TX 78701 (US)
Priority Data:
60/863,255 27.10.2006 US
Title (EN) METHODS AND COMPOSITIONS RELATED TO WRAPPING OF DEHYDRONS
(FR) PROCÉDÉS ET COMPOSITIONS LIÉS AUX ENVELOPPEMENTS DE DÉSHYDRONS
Abstract: front page image
(EN)This application describes a novel technology in drug discovery and drug-based imaging/detection: the wrapping technology. This technology is based on identified singularities in the structure of soluble proteins. In contrast with drug-design approaches based on standard structural considerations, the packing of a protein, or more precisely, its dehydron pattern, may be used as a selectivity filter to design small-molecule inhibitors. The wrapping technology described herein is a novel form of rational drug design for avoiding side effects in drug therapy and sharpening the inhibitory impact of drugs on the oncokinome.
(FR)L'invention concerne une nouvelle technologie dans la découverte de médicaments et l'imagerie/détection à base de médicaments : la technologie d'enveloppement. Cette technologie est basée sur des singularités identifiées dans la structure de protéines solubles. Contrairement à des approches de conception de médicament basées sur des considérations structurelles types, le garnissage d'une protéine, ou plus précisément son motif déshydron peut être utilisé comme filtre sélectif pour concevoir des inhibiteurs à petite molécule. La technologie d'enveloppement décrite ici est une nouvelle forme de conception rationnelle de médicaments pour éviter les effets secondaires de la thérapie médicamenteuse et affiner l'impact inhibiteur des médicaments sur l'oncokinome.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)