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1. (WO2003092619) PREVENTION AND TREATMENT OF TYPE 2 DIABETES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/092619    International Application No.:    PCT/US2003/013820
Publication Date: 13.11.2003 International Filing Date: 30.04.2003
Chapter 2 Demand Filed:    29.10.2003    
IPC:
A61K 39/00 (2006.01)
Applicants: WYETH HOLDINGS CORPORATION [US/US]; Five Giralda Farms, Madison, NJ 07940 (US) (For All Designated States Except US).
SIBER, George, Rainer [US/US]; (US) (For US Only).
PILLAI, Subramonia, Padmanabha [US/US]; (US) (For US Only).
FERNSTEN, Philip, David [US/US]; (US) (For US Only)
Inventors: SIBER, George, Rainer; (US).
PILLAI, Subramonia, Padmanabha; (US).
FERNSTEN, Philip, David; (US)
Agent: CALNAN, William, H.; Wyeth, Patent Law Department, Five Giralda Farms, Madison, NJ 07940 (US).
ROZEK, Carol, E.; Wyeth, Patent Law Department, Five Giralda Farms, Madison, NJ 07940 (US)
Priority Data:
60/376,618 30.04.2002 US
Title (EN) PREVENTION AND TREATMENT OF TYPE 2 DIABETES
(FR) PREVENTION ET TRAITEMENT DU DIABETE DE TYPE 2
Abstract: front page image
(EN)Methods and compositions are provided to prevent or treat Type 2 diabetes. Such methods entail administering an agent that induces in the patient a beneficial immune response against islet amyloid fibrils, protofibrils and/or amyloid plaque deposited in the islets of the human pancreas. In such methods, a suitable agent is an antigen that is surface-exposed only in islet amyloid fibrils, protofibrils, protofibrils and/or amyloid plaque but not in soluble, native islet amyloid polypeptide (IAPP), or an antibody thereto.
(FR)L'invention concerne des méthodes et des compositions destinées à prévenir ou traiter le diabète de type 2. Ces méthodes consistent à administrer un agent induisant chez le patient une réponse immunitaire favorable contre les fibrilles amyloïdes des îlots, les protofibrilles et/ou la plaque amyloïde se déposant dans les îlots du pancréas humain. Dans ces méthodes, un agent approprié est un antigène exposé en surface uniquement dans les fibrilles amyloïdes des îlots, les protofibrilles et/ou la plaque amyloïde, mais pas dans un polypeptide amyloïde des îlots (IAPP) natif soluble, ou un anticorps dirigé contre celles-ci.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)