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1. (WO2000064899) TETRACYCLIC AZEPINOINDOLE COMPOUNDS AS 5-HT RECEPTOR LIGANDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2000/064899    International Application No.:    PCT/US2000/010600
Publication Date: 02.11.2000 International Filing Date: 20.04.2000
Chapter 2 Demand Filed:    17.11.2000    
IPC:
C07D 471/16 (2006.01), C07D 498/16 (2006.01), C07D 513/16 (2006.01)
Applicants: PHARMACIA & UPJOHN COMPANY [US/US]; 301 Henrietta Street, Kalamazoo, MI 49001 (US) (For All Designated States Except US).
HESTER, Jackson, B., Jr. [US/US]; (US) (For US Only).
ROGERS, Bruce, N. [US/US]; (US) (For US Only).
JACOBSEN, E., Jon [US/US]; (US) (For US Only).
ENNIS, Michael, Dalton [US/US]; (US) (For US Only).
ACKER, Brad, A. [US/US]; (US) (For US Only).
VANDER VELDE, Susan, L. [US/US]; (US) (For US Only).
FRANK, Kristine, E. [US/US]; (US) (For US Only)
Inventors: HESTER, Jackson, B., Jr.; (US).
ROGERS, Bruce, N.; (US).
JACOBSEN, E., Jon; (US).
ENNIS, Michael, Dalton; (US).
ACKER, Brad, A.; (US).
VANDER VELDE, Susan, L.; (US).
FRANK, Kristine, E.; (US)
Agent: VIKSNINS, Ann, S.; Schwegman, Lundberg, Woessner & Kluth, P.O. Box 2938, Minneapolis, MN 55402 (US).
MCCRACKIN, Ann, M.; Schwegman, Lundberg, Woessner & Kluth, P.O. Box 2938, Minneapolis, MN 55402 (US)
Priority Data:
60/130,811 23.04.1999 US
Title (EN) TETRACYCLIC AZEPINOINDOLE COMPOUNDS AS 5-HT RECEPTOR LIGANDS
(FR) COMPOSES D'AZEPINOINDOLE TETRACYCLIQUE UTILISES COMME LIGANDS RECEPTEURS DE 5-HT
Abstract: front page image
(EN)The present invention provides compounds of formula (I), wherein R¿2? is hydrogen, C¿1-7?alkyl, C¿1-7?alkanoyl, arylcarbonyl, aryl, (aryl)C¿1-7?alkyl, C¿1-7?alkoxycarbonyl, aryloxycarbonyl, arylsulfonyl, or (aryl)C¿1-7?alkoxycarbonyl; X and Y together are 2, 3 or 4 membered saturated or partially unsaturated chain. These compounds are 5-HT ligands, and are useful for treating diseases wherein modulation of 5-HT activity is desired.
(FR)La présente invention concerne des composés de la formule (I), dans laquelle R¿2? est hydrogène, C¿1-7?alkyle, C¿1-7?alcanoyle, arylcarbonyle, aryle, (aryl)C¿1-7?alkyle, C¿1-7?alcoxycarbonyle, aryloxycarbonyle, arylsulfonyle, ou (aryl)C¿1-7?alcoxycarbonyle, X et Y étant tous les deux une chaîne saturée ou partiellement insaturée à 2, 3 ou 4 éléments. Ces composés sont des ligands 5-HT utilisés dans les traitements de maladies nécessitant une modulation de l'activité 5-HT.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Org. (ARIPO) (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)