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1. (WO2011153525) METHODS FOR TREATMENT OF NEPHROTIC SYNDROME AND RELATED CONDITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/153525    International Application No.:    PCT/US2011/039255
Publication Date: 08.12.2011 International Filing Date: 06.06.2011
IPC:
A61K 38/16 (2006.01), A61K 38/17 (2006.01), A61P 17/00 (2006.01), A61P 3/00 (2006.01), A61P 3/10 (2006.01)
Applicants: The UAB Research Foundation [US/US]; 1120G Administration Building 701 South 20th Street Birmingham, Alabama 35203 (US) (For All Designated States Except US).
CHUGH, Sumant [US/US]; (US) (For US Only)
Inventors: CHUGH, Sumant; (US)
Agent: LANDAU, Nicholas; Bradley Arant Boult Cummings, LLP 1819 5th Avenue North Birmingham, Alabama 35203 (US)
Priority Data:
61/351,866 05.06.2010 US
Title (EN) METHODS FOR TREATMENT OF NEPHROTIC SYNDROME AND RELATED CONDITIONS
(FR) MÉTHODES DE TRAITEMENT DU SYNDROME NÉPHROTIQUE ET ÉTATS APPARENTÉS
Abstract: front page image
(EN)The present disclosure provides a method for treating and/or preventing nephrotic syndrome, such as but not limited to MCD and MN, and conditions related to nephrotic syndrome, such as but not limited to, proteinuria and edema, as well as diabetic nephropathy, diabetes mellitus, lupus nephritis or primary glomerular disease. The present disclosure further provides methods for reducing proteinuria and other disease states as discussed herein. Such methods comprise the therapeutic delivery of an Angptl4 polypeptide or Angptl4 polypeptide derivative to a subject.
(FR)La présente invention concerne une méthode de traitement et/ou de prévention du syndrome néphrotique tel que, mais pas exclusivement, la maladie de changement minimal et la glomérulonéphrite extra-membraneuse (GEM), et des états associés au syndrome néphrotique tels que, mais pas exclusivement, la protéinurie et l'oedème, ainsi que la néphropathie diabétique, le diabète sucré, la néphropathie lupique ou la glomérulonéphrite primaire. La présente invention concerne également des méthodes visant à réduire la protéinurie, et d'autres états pathologiques évoqués dans le descriptif. Ces méthodes comprennent l'administration thérapeutique à un sujet d'un polypeptide Angptl4 ou d'un dérivé du polypeptide Angptl4.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)