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1. (WO2011075692) AQUEOUS COMPOSITIONS AND METHODS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/075692    International Application No.:    PCT/US2010/061136
Publication Date: 23.06.2011 International Filing Date: 17.12.2010
IPC:
G01N 37/00 (2006.01)
Applicants: NATIVIS, INC. [US/US]; 10975 N. Torrey Pines Road, Suite 150 La Jolla, CA 92037 (US) (For All Designated States Except US).
BUTTERS, B., Michael [US/US]; (US) (For US Only).
BUTTERS, John, T. [US/US]; (US) (For US Only).
BONZON, Christine [US/US]; (US) (For US Only).
GYMNOPOULOS, Marco [US/US]; (US) (For US Only).
CAMACHO, Mayra, Montes [US/US]; (US) (For US Only)
Inventors: BUTTERS, B., Michael; (US).
BUTTERS, John, T.; (US).
BONZON, Christine; (US).
GYMNOPOULOS, Marco; (US).
CAMACHO, Mayra, Montes; (US)
Agent: DEHLINGER, Peter, J.; King and Spalding P.O. Box 889 Belmont, CA 94002-0889 (US)
Priority Data:
61/287,559 17.12.2009 US
Title (EN) AQUEOUS COMPOSITIONS AND METHODS
(FR) COMPOSITIONS AQUEUSES ET PROCÉDÉS CORRESPONDANTS
Abstract: front page image
(EN)A method of forming an aqueous composition effective to produce an agent- specie effect on an agent-responssve chemical or biological system, when the composition is added to the system, ss disclosed. The composition is formed by exposing an aqueous medium to a tow-frequency, time-domain signal derived from the agent, until the aqueous medium acquires a detectable agent activity. Exemplary compositions are formed by exposure to a paclitaxei signal or a signal derived from a therapeutic oligonucleotide, such as GAPDH antisense RNA and PCSK9 antisense RNA Also disclosed are methods for confirming the activity of the composition, and for preparing and testing the activity of the compositions
(FR)L'invention concerne un procédé de formation d'une composition aqueuse efficace pour produire un effet spécifique à l'agent sur un système chimique ou biologique sensible à l'agent, lorsque la composition est ajoutée au système. La composition est formée par l'exposition d'un milieu aqueux à un signal en domaine temporel, basse fréquence, issu de l'agent, jusqu'à ce que le milieu aqueux acquière une activité d'agent détectable. Des compositions à titre d'exemples sont formées par l'exposition à un signal paclitaxel ou un signal issu d'un oligonucléotide thérapeutique, tel que l'ARN antisens de GAPDH et l'ARN antisens de PCSK9. L'invention concerne également des procédés de confirmation de l'activité de la composition, et de préparation et de test de l'activité des compositions.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)