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1. (WO2011002926) ISOLATED ADULT CELLS, ARTIFICIAL ORGANS,REHABILITATED ORGANS, RESEARCH ROOLS, ORGAN ENCASEMENTS, ORGAN PERFUSION SYSTEMS, AND METHODS FOR PREPARING AND UTILIZING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/002926    International Application No.:    PCT/US2010/040663
Publication Date: 06.01.2011 International Filing Date: 30.06.2010
IPC:
C12N 5/07 (2010.01), A01N 1/02 (2006.01), A61F 2/02 (2006.01)
Applicants: THE GENERAL HOSPITAL CORPORATION [US/US]; 55 Fruit Stret Boston, MA 02114 (US) (For All Designated States Except US).
MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; 77 Massachusetts Avenue Cambridge, MA 02139 (US) (For All Designated States Except US).
YARMUSH, Martin [US/US]; (US) (For US Only).
UYGUN, Basak, E. [TR/US]; (US) (For US Only).
UYGUN, Korkut [TR/US]; (US) (For US Only).
IZAMIS, Maria, Louisa [CY/US]; (US) (For US Only).
SOTO-GUTIERREZ, Alejandro [MX/US]; (US) (For US Only).
TOLBOOM, Herman [NL/CH]; (CH) (For US Only).
YAGI, Hiroshi [JP/US]; (US) (For US Only).
SHULMAN, Carley [US/US]; (US) (For US Only).
MILWID, Jack [US/US]; (US) (For US Only)
Inventors: YARMUSH, Martin; (US).
UYGUN, Basak, E.; (US).
UYGUN, Korkut; (US).
IZAMIS, Maria, Louisa; (US).
SOTO-GUTIERREZ, Alejandro; (US).
TOLBOOM, Herman; (CH).
YAGI, Hiroshi; (US).
SHULMAN, Carley; (US).
MILWID, Jack; (US)
Agent: LAURO, Peter C.; Edwards Angell Palmer & Dodge LLP P.O.Box 55874 Boston, MA 02205 (US)
Priority Data:
61/304,860 16.02.2010 US
61/222,266 01.07.2009 US
61/330,959 04.05.2010 US
Title (EN) ISOLATED ADULT CELLS, ARTIFICIAL ORGANS,REHABILITATED ORGANS, RESEARCH ROOLS, ORGAN ENCASEMENTS, ORGAN PERFUSION SYSTEMS, AND METHODS FOR PREPARING AND UTILIZING THE SAME
(FR) CELLULES ADULTES ISOLÉES, ORGANES ARTIFICIELS, ORGANES RÉHABILITÉS, OUTILS DE RECHERCHE, REVÊTEMENTS D'ORGANE, SYSTÈMES DE PERFUSION D'ORGANE, ET MÉTHODES DE PRÉPARATION ET D'UTILISATION DE CEUX-CI
Abstract: front page image
(EN)One aspect of the invention provides a method for harvesting adult cells from an organ. The method includes perfusing the organ with a perfusate and isolating adult cells from the organ, thereby harvesting the adult cells from the organ. Another aspect of the invention provides a method for rehabilitating an organ. The method includes: dividing the organ into a first portion and a second portion, perfusing the first portion with a decellularization medium, isolating adult cells from the second portion, and recellularizing the first portion with a suspension of the adult cells, thereby rehabilitating the organ.
(FR)La présente invention concerne, dans un aspect, une méthode de récolte de cellules adultes provenant d'un organe. Ladite méthode comprend la perfusion de l'organe au moyen d'un liquide de perfusion et l'isolation de cellules adultes provenant de l'organe, ce qui permet la récolte de cellules adultes provenant de l'organe. L'invention concerne, dans un autre aspect, une méthode de réhabilitation d'un organe. Ladite méthode comprend les éléments suivants : division de l'organe en une première partie et en une seconde partie ; perfusion de la première partie au moyen d'un milieu de décellularisation ; isolement de cellules adultes provenant de la seconde partie ; et recellularisation de la première partie avec une suspension des cellules adultes, permettant ainsi la réhabilitation de l'organe.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)