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1. (WO2010132886) COMPOSITIONS AND METHODS RELATING TO XMRV-RELATED DISEASES AND CONDITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/132886    International Application No.:    PCT/US2010/035144
Publication Date: 18.11.2010 International Filing Date: 17.05.2010
IPC:
C12Q 1/04 (2006.01), C07K 16/08 (2006.01), C12N 7/00 (2006.01), G01N 33/53 (2006.01)
Applicants: THE UNIVERSITY OF UTAH RESEARCH FOUNDATION [US/US]; 615 Arapeen Drive, Suite 310 Salt Lake City, Utah 84108 (US) (For All Designated States Except US).
SINGH, Ila Ramnaresh [US/US]; (US) (For US Only).
THAKER, Harshwardhan Manohar [US/US]; (US) (For US Only).
SCHLABERG, Robert [DE/US]; (US) (For US Only).
SHIN, Clifford [US/US]; (US) (For US Only)
Inventors: SINGH, Ila Ramnaresh; (US).
THAKER, Harshwardhan Manohar; (US).
SCHLABERG, Robert; (US).
SHIN, Clifford; (US)
Agent: MEARA, Joseph P.; c/o Foley & Lardner LLP 150 East Gilman Street Post Office Box 1497 Madison, Wisconsin 53701-1497 (US)
Priority Data:
61/216,317 15.05.2009 US
61/239,220 02.09.2009 US
61/247,903 01.10.2009 US
Title (EN) COMPOSITIONS AND METHODS RELATING TO XMRV-RELATED DISEASES AND CONDITIONS
(FR) COMPOSITIONS ET MÉTHODES APPLIQUÉES À DES MALADIES ET DES TROUBLES ASSOCIÉS À XMRV
Abstract: front page image
(EN)Disclosed herein are methods and compositions relating to the diagnosis of XMRV infection and XMRV-related diseases, including but not limited to malignancies such as prostate cancer, lymphomas, leukemias, myelodysplastic diseases, thymomas and also non-cancerous conditions such as chronic fatigue syndrome, and other neuroimmune disorders. The methods involve detection of XMRV RNA or DNA, or XMRV proteins, or antibodies to XMRV, and the use of these methods for diagnosis, for monitoring the progression of disease, and in monitoring treatment efficacy of various XMRV-associated diseases. Also disclosed herein are methods and compositions relating to the assessment of the cancer grade and long-term prognosis of a subject with cancer through the detection of anti-XMRV antibodies.
(FR)L'invention porte sur des méthodes et des compositions appliquées au diagnostic d'une infection par XMRV et des maladies associées à XMRV, comprenant mais sans y être limité des tumeurs malignes telles qu'un cancer de la prostate, des lymphomes, des leucémies, des maladies myélodysplasiques, des thymomes et également des troubles non cancéreux tels qu'un syndrome de fatigue chronique et autres troubles neuroimunologiques. Les méthodes mettent en jeu la détection d'ARN ou d'ADN de XMRV ou de protéines de XMRV, ou d'anticorps dirigés contre XMRV. L'invention porte également sur l'utilisation de ces méthodes pour diagnostiquer, surveiller la progression d'une maladie et l'efficacité thérapeutique de diverses maladies associées à XMRV. L'invention porte également sur des méthodes et des compositions appliquées à l'évaluation du stade d'un cancer et au pronostic à long terme d'un sujet atteint d'un cancer par détection d'anticorps anti-XMRV.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)