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1. (WO2010046775) METHODS FOR PRODUCING ANTIBODIES FROM PLASMA CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/046775    International Application No.:    PCT/IB2009/007375
Publication Date: 29.04.2010 International Filing Date: 22.10.2009
IPC:
C07K 16/00 (2006.01), C07K 16/10 (2006.01), C07K 16/12 (2006.01), C12N 5/0781 (2010.01)
Applicants: INSTITUTE FOR RESEARCH IN BIOMEDICINE [CH/CH]; Via Vela 6 CH-5400 Bellinzona (CH) (For All Designated States Except US).
LANZAVECCHIA, Antonio [CH/CH]; (CH) (For US Only).
JARROSSAY, David [CH/CH]; (CH) (For US Only)
Inventors: LANZAVECCHIA, Antonio; (CH).
JARROSSAY, David; (CH)
Agent: SMAGGASGALE, Gillian Helen; W.P. Thompson & Co. 55 Drury Lane London WC2B 5SQ (GB)
Priority Data:
0819376.5 22.10.2008 GB
61/181,582 27.05.2009 US
PCT/IB2009/006616 27.07.2009 IB
12/509,731 27.07.2009 US
Title (EN) METHODS FOR PRODUCING ANTIBODIES FROM PLASMA CELLS
(FR) PROCÉDÉS POUR PRODUIRE DES ANTICORPS À PARTIR DE PLASMOCYTES
Abstract: front page image
(EN)The invention relates to methods of producing antibodies, including monoclonal antibodies, comprising culturing a limited number of plasma cells. It also relates to methods of identifying antibodies by performing assays on the antibodies produced by the cultured plasma cells to determine their function, binding specificity, epitope specificity, and/or their ability to neutralize a toxin or a pathogen. The invention also relates to antibodies and antibody fragments produced by the methods of the invention as well as methods of using the antibodies and antibody fragments.
(FR)La présente invention concerne des procédés de production d’anticorps, comprenant des anticorps monoclonaux, comprenant la culture d’un nombre limité de plasmocytes. Elle concerne en outre des procédés d’identification d’anticorps en effectuant des essais sur les anticorps produits par les plasmocytes cultivés pour déterminer leurs fonction, spécificité de liaison, spécificité d’épitope et/ou leur capacité à neutraliser une toxine ou un pathogène. L’invention concerne en outre des anticorps et des fragments d’anticorps produits par les procédés de l’invention ainsi que des procédés d’utilisation des anticorps et fragments d’anticorps.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)