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1. (WO2009064590) THERAPEUTIC APPLICATIONS OF P53 ISOFORMS IN REGENERATIVE MEDICINE, AGING AND CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/064590    International Application No.:    PCT/US2008/080648
Publication Date: 22.05.2009 International Filing Date: 21.10.2008
IPC:
C12N 15/11 (2006.01), A61K 31/7105 (2006.01), A61K 31/711 (2006.01), A61K 31/713 (2006.01), A61P 35/00 (2006.01)
Applicants: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Office of Technology Transfer, 6011 Executive Boulevard, Suite 325, Rockville, Maryland 20852-3804 (US) (For All Designated States Except US).
HARRIS, Curtis C. [US/US]; (US) (For US Only).
FUJITA, Kaori [JP/US]; (US) (For US Only).
HORIKAWA, Izumi [JP/US]; (US) (For US Only).
VOJTESEK, Borivoj [CZ/CZ]; (CZ).
BOURDON, Jean-christophe [FR/GB]; (FR) (For US Only).
LANE, David P. [GB/GB]; (GB) (For US Only)
Inventors: HARRIS, Curtis C.; (US).
FUJITA, Kaori; (US).
HORIKAWA, Izumi; (US).
VOJTESEK, Borivoj; (CZ).
BOURDON, Jean-christophe; (FR).
LANE, David P.; (GB)
Agent: GAO, Chuan; Townsend and Townsend and Crew LLP, 2 Embarcadero Center, 8th Floor, San Francisco, California 94111-3834 (US)
Priority Data:
60/987,340 12.11.2007 US
Title (EN) THERAPEUTIC APPLICATIONS OF P53 ISOFORMS IN REGENERATIVE MEDICINE, AGING AND CANCER
(FR) APPLICATIONS THÉRAPEUTIQUES DES ISOFORMES P53 EN MÉDECINE RÉGÉNÉRATRICE, POUR LUTTER CONTRE LE VIEILLISSEMENT ET LE CANCER
Abstract: front page image
(EN)The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation.
(FR)La présente invention concerne des procédés et des compositions pour moduler la sénescence cellulaire et la prolifération cellulaire avec des isoformes de la protéine suppresseur de tumeur p53. Les procédés et les compositions de l'invention sont utiles pour inhiber la croissance cellulaire cancéreuse ou pour générer des populations de cellules à des fins de régénération tissulaire par modulation de la sénescence et de la prolifération cellulaires.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)