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1. (WO2008109068) A CONJUGATE OF INSULIN AND VITAMIN B12 FOR ORAL DELIVERY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/109068    International Application No.:    PCT/US2008/002846
Publication Date: 12.09.2008 International Filing Date: 04.03.2008
IPC:
A61K 38/22 (2006.01), A61K 38/26 (2006.01), A61K 38/28 (2006.01), A61K 47/48 (2006.01)
Applicants: SYRACUSE UNIVERSITY [US/US]; 2-220 CST, Syracuse, New York 13244-1200 (US) (For All Designated States Except US).
DOYLE, Robert, Patrick [IE/US]; (US) (For US Only)
Inventors: DOYLE, Robert, Patrick; (US)
Agent: DELANEY, Karoline A.; Knobbe, Martens, Olson & Bear, LLP, 2040 Main Street, 14th Floor, Irvine, California 92614 (US)
Priority Data:
60/904,962 05.03.2007 US
Title (EN) A CONJUGATE OF INSULIN AND VITAMIN B12 FOR ORAL DELIVERY
(FR) CONJUGUÉ D'INSULINE ET DE VITAMINE B12 POUR ADMINISTRATION ORALE
Abstract: front page image
(EN)Compositions containing a therapeutic peptide covalently linked to Vitamin B12 at the 5'-hydroxyl group of the ribose moiety of α-ligand are described. The length of the linkage is optimized so that the biological activity of both the Vitamin B12 and the therapeutic peptide is maintained. Therapeutic peptide includes insulin, PYY, NPY and GLP-1. Attachment to Vitamin B12 provides uptake of the therapeutic peptide from the digestive tract and longer residence time.
(FR)L'invention concerne des compositions contenant un peptide thérapeutique, lié de manière covalente à la vitamine B12 sur le groupe 5'-hydroxyle de la partie ribose du ligand α. La longueur de la liaison est optimalisée de façon à conserver l'activité biologique de la vitamine B12 et du peptide thérapeutique. Le peptide thérapeutique comprend l'insuline, PYY, NPY et GLP-1. L'attachement à la vitamine B12 procure l'absorption du peptide thérapeutique depuis le tractus digestif et un temps de séjour plus long.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)