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1. (WO2008063769) PROSTATE CANCER-SPECIFIC ALTERATIONS IN ERG GENE EXPRESSION AND DETECTION AND TREATMENT METHODS BASED ON THOSE ALTERATIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/063769    International Application No.:    PCT/US2007/080826
Publication Date: 29.05.2008 International Filing Date: 09.10.2007
IPC:
C12Q 1/68 (2006.01)
Applicants: THE HENRY M.JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. [US/US]; 1401 Rockville Pike, Suite 600, Rockville, MD 20852 (US) (For All Designated States Except US).
SRIVASTAVA, Shiv [US/US]; (US) (For US Only).
DOBI, Albert [HU/US]; (US) (For US Only).
SREENATH, Taduru [US/US]; (US) (For US Only).
PETROVICS, Gyorgy [US/US]; (US) (For US Only).
SUN, Chen [CN/US]; (US) (For US Only)
Inventors: SRIVASTAVA, Shiv; (US).
DOBI, Albert; (US).
SREENATH, Taduru; (US).
PETROVICS, Gyorgy; (US).
SUN, Chen; (US)
Agent: DONALDSON, Timothy, B.; Latimer, Mayberry & Matthews IP Law, LLP, 13873 Park Center Road, Suite 106, Herndon, VA 20171 (US)
Priority Data:
60/850,254 10.10.2006 US
60/929,505 29.06.2007 US
Title (EN) PROSTATE CANCER-SPECIFIC ALTERATIONS IN ERG GENE EXPRESSION AND DETECTION AND TREATMENT METHODS BASED ON THOSE ALTERATIONS
(FR) ALTÉRATIONS DE L'EXPRESSION DU GÈNE ERG SPÉCIFIQUES AU CANCER DE LA PROSTATE, ET PROCÉDÉS DE DÉTECTION ET DE TRAITEMENT EN FONCTION DE CES ALTÉRATIONS
Abstract: front page image
(EN)The disclosure describes alterations in ERG gene expression. ERG isoforms and promoter sequence of the ERG gene that are involved in, or associated with, prostate cancer are provided. The disclosure further provides therapeutic compositions and methods of detecting, diagnosing, prognosing, and treating prostate cancer, including biomarkers for detecting the expression of two or more of the following genes: PSA/KLK3, PMEPA1, NKX3.1, ODC1, AMD1, and ERG.
(FR)L'invention décrit des altérations de l'expression du gène ERG. Sont fournies des isoformes d'ERG et une séquence de promoteurs du gène ERG impliqués dans le cancer de la prostate ou associés à celui-ci. L'invention fournit en outre des compositions thérapeutiques et des procédés pour détecter, diagnostiquer, pronostiquer et traiter un cancer de la prostate, y compris des biomarqueurs pour détecter l'expression de deux des gènes suivants ou plus : PSA/KLK3, PMEPM, NKX3.1, ODC1, AMD1, et ERG.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)