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1. (WO2008057254) TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/057254    International Application No.:    PCT/US2007/022651
Publication Date: 15.05.2008 International Filing Date: 26.10.2007
IPC:
C07D 307/91 (2006.01), A61K 31/343 (2006.01), A61K 31/381 (2006.01), A61K 31/4155 (2006.01), A61K 31/4192 (2006.01), A61K 31/443 (2006.01), A61K 31/5377 (2006.01), C07D 333/76 (2006.01), C07D 405/04 (2006.01), C07D 409/12 (2006.01), C07D 409/14 (2006.01), C07D 413/04 (2006.01), C07D 413/12 (2006.01), C07D 417/04 (2006.01), C07D 417/12 (2006.01)
Applicants: WYETH [US/US]; Five Giralda Farms, Madison, NJ 07940 (US) (For All Designated States Except US).
LI, Wei [CN/US]; (US) (For US Only).
LI, Jianchang [US/US]; (US) (For US Only).
WU, Yuchuan [CN/US]; (US) (For US Only).
TAM, Steve [US/US]; (US) (For US Only).
MANSOUR, Tarek [CA/US]; (US) (For US Only).
SYPEK, Joseph, P. [US/US]; (US) (For US Only).
MCFAYDEN, Iain [GB/US]; (US) (For US Only).
HOTCHANDANI, Rajeev [IN/US]; (US) (For US Only).
WU, Junjun [US/US]; (US) (For US Only)
Inventors: LI, Wei; (US).
LI, Jianchang; (US).
WU, Yuchuan; (US).
TAM, Steve; (US).
MANSOUR, Tarek; (US).
SYPEK, Joseph, P.; (US).
MCFAYDEN, Iain; (US).
HOTCHANDANI, Rajeev; (US).
WU, Junjun; (US)
Agent: BARNHARD, Elizabeth, M.; Wyeth, Patent Law Department, Five Giralda Farms, Madison, New Jersey 07076 (US)
Priority Data:
60/854,786 27.10.2006 US
Title (EN) TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS
(FR) COMPOSÉS TRICYCLIQUES SERVANT D'INHIBITEURS DES MÉTALLOPROTÉASES MATRICIELLES
Abstract: front page image
(EN)The present invention relates to compositions of the formula (I): and pharmaceutically acceptable salts, hydrates, or esters thereof, wherein R1, R2, R3, R4, R5, X, and Y are as defined herein. The present teachings also provide methods of making the compounds of formula I, and methods of treating pathologic conditions or disorders mediated wholly or in part by matrix metalloproteinases, such as asthma and chronic obstructive pulmonary disease, comprising administering a therapeutically effective amount of a compound of formula (I) to a mammal (e.g., a human) in need thereof.
(FR)La présente invention concerne des composés de formule (I) : et des sels, hydrates ou esters acceptables du point de vue pharmaceutique de ceux-ci, R1, R2, R3, R4, R5, X et Y étant tels que définis ici. La présente invention concerne également des procédés de fabrication des composés de formule (I) et des procédés de traitement d'affections ou troubles pathologiques induits entièrement ou en partie par des métalloprotéases matricielles, tels que l'asthme et une bronchopneumopathie chronique obstructive, lesquels consistent à administrer une quantité efficace du point de vue thérapeutique d'un composé de formule (I) à un mammifère (par exemple à un humain) qui en a besoin.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)