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1. (WO2006078941) NOVEL SIRTUIN ACTIVATING COMPOUNDS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/078941    International Application No.:    PCT/US2006/002092
Publication Date: 27.07.2006 International Filing Date: 20.01.2006
IPC:
C07D 403/04 (2006.01), A61K 31/4025 (2006.01), A61P 3/10 (2006.01)
Applicants: SIRTRIS PHARMACEUTICALS, INC. [US/US]; 790 Memorial Drive, Suite 104, Cambridge, Massachusetts 02139 (US) (For All Designated States Except US).
MILBURN, Michael [US/US]; (US) (For US Only).
ECKSTEIN, Jens, W. [DE/US]; (US) (For US Only)
Inventors: MILBURN, Michael; (US).
ECKSTEIN, Jens, W.; (US)
Agent: VINCENT, Matthew, P.; Fish & Neave IP Group, Ropes & Gray LLP, One International Place, Boston, Massachusetts 02110-2624 (US)
Priority Data:
60/645,916 20.01.2005 US
Title (EN) NOVEL SIRTUIN ACTIVATING COMPOUNDS AND METHODS OF USE THEREOF
(FR) NOUVEAUX COMPOSES D'ACTIVATION DE LA SIRTUINE ET PROCEDES D'UTILISATION ASSOCIES
Abstract: front page image
(EN)Provided herein are novel sirtuin-activating compounds and methods of use thereof. The sirtuin-activating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing. Also provided are compositions comprising a sirtuin-activating compound in combination with another therapeutic agent.
(FR)L'invention concerne des nouveaux composés d'activation de la sirtuine et des procédés d'utilisation de ceux-ci. Lesdits composés d'activation de la sirtuine peuvent être utilisés pour augmenter la durée de vie d'une cellule, et pour traiter et/ou prévenir des maladies et des troubles divers, de type : maladies ou troubles associés au vieillissement ou au stress, diabète, obésité, maladies neurodégéneratives, maladies cardiovasculaires, troubles de la coagulation sanguine, inflammation, cancer, et/ou bouffées vasomotrices. L'invention concerne également des compositions comprenant un composé d'activation de la sirtuine en combinaison avec un autre agent thérapeutique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)