NL2003000728 SYSTEM FOR EARLY DETECTION OF DISEASE AND DEVELOPMENT OF DISEASE-SPECIFIC BIOMARKERS

1. (WO2004038444) SYSTEM FOR EARLY DETECTION OF DISEASE AND DEVELOPMENT OF DISEASE-SPECIFIC BIOMARKERS

Notices

Latest bibliographic data on file with the International Bureau

Pub. No.:		WO/2004/038444		International Application No.:		PCT/NL2003/000728
Publication Date:		06.05.2004		International Filing Date:		27.10.2003

IPC:

G01R 33/465 (2006.01)

Applicants:

NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO [NL/NL]; Schoemakerstraat 97, NL-2628 VK Delft (NL) (For All Designated States Except US).
VAN NESSELROOY, Johannes, Henricus, Joseph [NL/NL]; (NL) (For US Only).
LAMERS, Robert-Jan, Antonius, Nicolaas [NL/NL]; (NL) (For US Only).
DE GROOT, Jeroen [NL/NL]; (NL) (For US Only).
VERZIJL, Nicole [NL/NL]; (NL) (For US Only)

Inventors:

VAN NESSELROOY, Johannes, Henricus, Joseph; (NL).
LAMERS, Robert-Jan, Antonius, Nicolaas; (NL).
DE GROOT, Jeroen; (NL).
VERZIJL, Nicole; (NL)

Agent:

PRINS, A., W.; Vereenigde, Johan de Wittlaan 7, NL-2517 JR Den Haag (NL)

Priority Data:

1021753

25.10.2002

Title

(EN) SYSTEM FOR EARLY DETECTION OF DISEASE AND DEVELOPMENT OF DISEASE-SPECIFIC BIOMARKERS
(FR) SYSTEME DE DETECTION PRECOCE DE MALADIE ET DEVELOPPEMENT DE BIOMARQUEURS SPECIFIQUES D'UNE MALADIE

Abstract:

(EN)The present invention relates to a method for the detection of a specific disease in a mammal, comprising providing an NMR spectrum of metabolites in a body fluid of an individual of said mammal in which said disease is suspected and comparing said NMR spectrum with a difference profile, comprising a plurality of NMR spectral line positions, which express the normalized difference between one or more NMR spectra of metabolites in a body fluid of one or more healthy individuals of said mammal, and one or more corresponding NMR spectra of metabolites in a corresponding body fluid of one or more individuals of said mammal in which the disease has been diagnosed. The invention also relates to the said difference profile for the detection of a disease in a mammal and to methods for the manufacture thereof. The invention also relates to a biomarker for detection of specific diseases, in particular osteoarthritis, and to the use of that biomarker in detection of osteoarthritis.
(FR)L'invention concerne une méthode de détection de maladie spécifique d'un mammifère. Ladite méthode consiste à fournir un spectre de résonance magnétique nucléaire (NMR) de métabolites dans un fluide corporel d'un individu mammifère chez lequel on suspecte une maladie, et à comparer ce spectre NMR avec un profil de différence comprenant une pluralité de positions de lignes spectrales NMR qui expriment la différence normalisée entre un ou plusieurs spectre(s) NMR de métabolites dans un fluide corporel correspondant d'un ou plusieurs individu(s) mammifère(s) sains chez lesquels on a diagnostiqué la maladie. L'invention concerne également le profil de différence permettant de détecter une maladie chez un mammifère, et les procédés de production de ces profils. L'invention concerne enfin un biomarqueur permettant de détecter des maladies spécifiques, en particulier, l'ostéoarthrite, et l'utilisation de ce biomarqueur pour détecter l'ostéoarthrite.

Designated States:

AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).

Publication Language:	English (EN)
Filing Language:	Dutch; Flemish (NL)